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首页> 外文期刊>Current opinion in HIV and AIDS >Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses.
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Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses.

机译：了解精英控制的动物模型：针对免疫缺陷病毒的有效免疫反应的窗口。

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PURPOSE OF REVIEW: We will summarize recent advances in research regarding control of simian immunodeficiency virus replication in nonhuman primate models. We will then relate these findings to the broader field of human immunodeficiency virus (HIV) vaccine development. RECENT FINDINGS: Recent studies have highlighted the importance of T-cell responses in elite control, especially CD8+ T-cell responses and provide insight into the kinetics and qualities of such effective responses. Additionally, these findings suggest that the peptides bound by elite control-associated major histocompatibility complex class I molecules in monkeys and humans share many properties. SUMMARY: Animal models of effective immune control of immunodeficiency virus replication have provided important insight into the components of successful immune responses against these viruses. Similarities between the human and nonhuman primate responses to immunodeficiency viruses should help us understand the nature of elite control. Further study of the acute phase, in which virus replication is first brought under control, may help define important characteristics of viral control that could be engendered by a successful HIV vaccine.
机译：审查的目的：我们将总结有关在非人类灵长类动物模型中控制猿猴免疫缺陷病毒复制的研究的最新进展。然后，我们将把这些发现与人类免疫缺陷病毒（HIV）疫苗开发的更广泛领域联系起来。最近的发现：最近的研究强调了T细胞应答在精英控制中的重要性，尤其是CD8 + T细胞应答，并为这种有效应答的动力学和质量提供了见识。另外，这些发现表明，在猴子和人类中，与精英控制相关的主要组织相容性复合物I类分子结合的肽具有许多特性。概述：有效免疫控制免疫缺陷病毒复制的动物模型为成功针对这些病毒的免疫应答提供了重要的见识。人类和非人类的灵长类动物对免疫缺陷病毒的反应之间的相似性应有助于我们了解精英控制的性质。对急性期的进一步研究（其中病毒复制首先受到控制）可能有助于确定成功的HIV疫苗可能引起的病毒控制的重要特征。

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