...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Treatment outcomes of patients with primary squamous cell carcinoma of the retromolar trigone
【24h】

Treatment outcomes of patients with primary squamous cell carcinoma of the retromolar trigone

机译：荆棘三角形初级鳞状细胞癌患者的治疗结果

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives/Hypothesis Squamous cell carcinoma of the retromolar trigone (RMT SCC) is a relatively uncommon primary site for oral cavity malignancy. However, given its proximity to the mandible and buccal mucosa, RMT SCC typically exhibits early invasion and generally presents at an advanced stage. Large-sample studies are needed to assess the epidemiology and clinical outcomes of this tumor. Our aim was to describe the determinants of survival in patients with RMT SCC. Study Design Retrospective cohort study. Methods Retrospective, population-based cohort study of patients in the Surveillance, Epidemiology, and End Results tumor registry who were diagnosed with RMT SCC from 1973 to 2012. Primary endpoints were overall survival (OS) and disease-specific survival (DSS). Results A total of 4,022 cases of RMT SCC were identified. The mean age at diagnosis was 65 years. Thirty-nine percent of cases presented with stage IV disease. The median OS by stages I to IV were 73.7, 52.4, 27.5, and 23.4 months, respectively (P .05). Overall, 34.3% of patients underwent surgery, 23.5% received radiation therapy, and 34.1% had both surgical and radiation therapy. On multivariate analysis, advanced age, greater tumor size, and advanced stage were associated with worse OS and DSS (P .05), surgery predicted improved OS and DSS (P .05), and radiation therapy predicted improved OS only (P .05). Conclusions RMT SCC is an aggressive malignancy that portends a poor prognosis, though early-stage tumors (stages I and II) have significantly improved survival. Any surgical intervention independently predicted higher survival outcomes. There may be a role of dual modality approaches, particularly for larger tumors.
机译：逆转三角形（RMT SCC）的目标/假设鳞状细胞癌是口腔恶性肿瘤的相对罕见的原始部位。然而，鉴于临近下颌骨和口腔粘膜，RMT SCC通常呈现早期入侵，一般在高级阶段提供。需要大型研究来评估这种肿瘤的流行病学和临床结果。我们的目的是描述RMT SCC患者的生存决定蛋白。研究设计回顾性队列研究。方法回顾性，患者患者的患者患者，流行病学和最终结果肿瘤登记处诊断为1973年至2012年诊断。初级终点是总生存（OS）和疾病特异性存活率（DSS）。结果鉴定了4,022例RMT SCC。诊断的平均年龄为65岁。 39％的病例患有阶段IV疾病。 STage I至IV的中值OS分别为73.7,52.4,27.5和23.4个月（P <.05）。总体而言，34.3％的患者接受手术，23.5％接受放射治疗，34.1％具有手术和放射治疗。关于多变量分析，晚期肿瘤大小和晚期阶段与更差的OS和DSS（P <.05），手术预测改进的OS和DSS（P <.05），以及放射治疗的进程仅预测改进的操作系统（P＆ .05）。结论RMT SCC是一种激进的恶性肿瘤，其预后不良，尽管早期肿瘤（阶段I和II）显着提高存活。任何手术干预都独立地预测了更高的生存结果。双重模型方法可能存在作用，特别是对于较大的肿瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号