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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Quantifying vocal fold wound‐healing biomechanical property changes
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Quantifying vocal fold wound‐healing biomechanical property changes

机译：量化声带伤口愈合生物力学性能变化

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Objectives Development of novel vocal fold (VF) therapeutics is limited by a lack of standardized, meaningful outcomes. We hypothesize that automated microindentation‐based VF biomechanical property mapping matched to histology permits quantitative assessment. Study Design Ex vivo. Methods Twelve anesthetized New Zealand white rabbits underwent endoscopic right VF injury. Larynges were harvested/bisected day 7, 30, or 60 (n = 4/group), with four uninjured controls. Biomechanical measurements (normal force, structural stiffness, and displacement at 1.96 mN) were calculated using automated microindentation mapping (0.3 mm depth, 1.2 mm/s, 2 mm spherical indenter) with a grid overlay (50 locations weighted toward VF edge, separated into 14 zones). Specimens were marked/fixed/sectioned, and slides matched to measurement points. Results In the injury zone, normal force/structural stiffness (mean, standard deviation [SD]/mean, SD) increased from uninjured (2.2 mN, 0.64/7.4 mN/mm, 2.14) and day 7 (2.7 mN, 0.75/9.0 mN/mm, 2.49) to day 30 (4.3 mN, 2.11/14.2 mN/mm, 7.05) and decreased at 60 days (2.7 mN, 0.77/9.1 mN/mm, 2.58). VF displacement decreased from control (0.28 mm, 0.05) and day 7 (0.26 mm, 0.05) to day 30 (0.20 mm, 0.05), increasing at day 60 (0.25 mm, 0.06). A one‐way ANOVA was significant; Tukey's post hoc test confirmed day‐30 samples differed from other groups ( P 0.05), consistent across adjacent zones. Zones far from injury remained similar across groups ( P = 0.143 to 0.551). These measurements matched qualitative histologic variations. Conclusion Quantifiable VF biomechanical properties can be linked to histology. This technological approach is the first to simultaneously correlate functional biomechanics with histology and is ideal for future preclinical studies. Level of Evidence NA Laryngoscope , 130:454–459, 2020
机译：目的通过缺乏标准化，有意义的成果的缺乏有限的新闻折叠（VF）治疗的目标。我们假设基于自动化的微观化的VF生物力学性质映射与组织学相匹配允许定量评估。研究设计前体内。方法十二点麻醉的新西兰白兔接受内窥镜右vf损伤。喉部被收获/二次被收获/二次出现的第7天，30或60（n = 4 /组），具有四种未受约束的对照。使用自动微图形映射（0.3mm深度，1.2mm / s，2mm球形压痕）计算生物力学测量（正常力，结构刚度和位移，在1.96mn下为1.2 mm / s，2mm球形压痕），具有网格覆盖（＆ 50位向VF边缘加权，分成14个区域）。标本标记/固定/切片标本，并与测量点相匹配。导致损伤区，正常力/结构刚度（平均值，标准偏差[SD] /平均值，SD）从未受到约束（2.2mN，0.64 / 7.4mN / mm，2.14）和第7天（2.7mN，0.75 / 9.0 Mn / mm，2.49）至第30天（4.3mN，2.11 / 14.2mn / mm，7.05），并在60天下降（2.7mn，0.77 / 9.1mN / mm，2.58）。 VF位移从对照（0.28mm，0.05）和第7天（0.26 mm，0.05）至第30天（0.20mm，0.05），在第60天增加（0.25mm，0.06）。单向ANOVA是重要的; Tukey的Hoc测试证实的一天-30个样本与其他组（P <0.05）不同，相邻区域一致。远离伤害的区域跨越群体相似（P = 0.143至0.551）。这些测量符合定性组织学变化。结论可量化的VF生物力学特性可以与组织学相连。这种技术方法是第一个与组织学同时关联功能生物力学，是未来临床前研究的理想选择。证据水平na喉镜，130：454-459,2020

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