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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Endoscopic Sealing With a Polyglycolic Acid Sheet for Restoration of Vocal Fold Mucosa in Dogs
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Endoscopic Sealing With a Polyglycolic Acid Sheet for Restoration of Vocal Fold Mucosa in Dogs

机译：用聚乙醇酸片用内窥镜密封，用于在狗中恢复声带粘膜

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Objectives/Hypothesis Voice outcomes of cordectomy for early glottic cancer are often poor due to vocal fold scarring and tissue defects. Improvements in this aspect could make cordectomy a more acceptable treatment option than radiotherapy. We hypothesized that a polyglycolic acid (PGA) sheet could be used to cover vocal fold defects. The present study aimed to prevent vocal fold scarring after cordectomy using the PGA sheet. Study Design Animal experiment. Methods Nine male beagles were divided into three groups including a control group (n = 3). Following cordectomy, the vocal fold defect was covered with the PGA sheet plus fibrin glue (PGA group; n = 3) or with the PGA sheet plus fibrin glue containing basic fibroblast growth factor (bFGF; the PGA‐bFGF group, n = 3). Vocal folds were chronologically observed, and larynges were removed 6 months after surgery. Mucosal amplitude was measured using a high‐speed camera, and histological analysis was performed. Results The re‐epithelialization process was delayed in the PGA and PGA‐bFGF groups compared with the control group. The mucosal amplitude was significantly more normalized and the thickness ratio significantly higher in the PGA and PGA‐bFGF groups compared with the control group. The PGA‐bFGF group had the highest elastic fiber density, followed by the PGA group and then the control group, with a significant difference between the PGA‐bFGF and control groups. Conclusions The PGA sheet plus fibrin glue could serve as an effective regenerative scaffold for reconstructing vocal fold morphology and function after cordectomy, with the potential benefit of establishing an endoscopic sealing method for vocal fold defects. Level of Evidence NA Laryngoscope , 130:E436–E443, 2020
机译：由于声带疤痕和组织缺陷，目前最剧性癌症的目的/假设语音结果通常差。在这方面的改进可以使肠切除术成为比放射疗法更可接受的治疗方案。我们假设可以使用聚乙醇酸（PGA）片来覆盖声带缺陷。本研究旨在使用PGA片材在肠切除术后的声带瘢痕。研究设计动物实验。方法将九只雄荆味分为三组，包括对照组（n = 3）。肠切除术后，用PGA板加上纤维蛋白胶（PGA组; N = 3）或PGA板加上含有碱性成纤维细胞生长因子（BFGF; PGA-BFGF组，N = 3）的PGA板胶囊覆盖。年按时间顺序观察到声带，手术后6个月除去喉部。使用高速相机测量粘膜振幅，并进行组织学分析。结果与对照组相比，在PGA和PGA-BFGF组中延迟重新上皮化过程。与对照组相比，粘膜振幅明显更高化，PGA和PGA-BFGF组中的厚度比显着高。 PGA-BFGF组具有最高的弹性纤维密度，其次是PGA组，然后对照组，PGA-BFGF和对照组之间具有显着差异。结论PGA板加上纤维蛋白胶可以作为用于重建声学折叠形态和功能后的有效再生支架的有效再生支架，具有建立声带缺损的内窥镜密封方法的潜在益处。证据水平na喉镜，130：E436-E443,2020

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