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首页> 外文期刊>The Journal of Physiology >Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration
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Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration

机译：内源性生物电网在开发和再生过程中储存非遗传图案化信息

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Pattern formation, as occurs during embryogenesis or regeneration, is the crucial link between genotype and the functions upon which selection operates. Even cancer and aging can be seen as challenges to the continuous physiological processes that orchestrate individual cell activities toward the anatomical needs of an organism. Thus, the origin and maintenance of complex biological shape is a fundamental question for cell, developmental, and evolutionary biology, as well as for biomedicine. It has long been recognized that slow bioelectrical gradients can control cell behaviors and morphogenesis. Here, I review recent molecular data that implicate endogenous spatio-temporal patterns of resting potentials among non-excitable cells as instructive cues in embryogenesis, regeneration, and cancer. Functional data have implicated gradients of resting potential in processes such as limb regeneration, eye induction, craniofacial patterning, and head-tail polarity, as well as in metastatic transformation and tumorigenesis. The genome is tightly linked to bioelectric signaling, via ion channel proteins that shape the gradients, downstream genes whose transcription is regulated by voltage, and transduction machinery that converts changes in bioelectric state to second-messenger cascades. However, the data clearly indicate that bioelectric signaling is an autonomous layer of control not reducible to a biochemical or genetic account of cell state. The real-time dynamics of bioelectric communication among cells are not fully captured by transcriptomic or proteomic analyses, and the necessary-and-sufficient triggers for specific changes in growth and form can be physiological states, while the underlying gene loci are free to diverge. The next steps in this exciting new field include the development of novel conceptual tools for understanding the anatomical semantics encoded in non-neural bioelectrical networks, and of improved biophysical tools for reading and writing electrical state information into somatic tissues. Cracking the bioelectric code will have transformative implications for developmental biology, regenerative medicine, and synthetic bioengineering.
机译：如在胚胎发生或再生期间发生的图案形成是基因型和选择操作的功能之间的关键链接。甚至癌症和衰老都可以被视为持续生理过程的挑战，使个体细胞活动朝向生物的解剖需求。因此，复杂生物形状的起源和维持是细胞，发育和进化生物学以及生物医学的基本问题。它已经很久认识到，慢生物电梯度可以控制细胞行为和形态发生。在这里，我审查了最近的分子数据，其致癌在非易激发细胞中静置电位的内源性时空模式作为胚胎发生，再生和癌症中的指导性提示。功能数据具有含有肢体再生，眼睛诱导，颅面图案化的过程中静息电位的梯度的梯度，以及转移转化和肿瘤发生。基因组通过离子通道蛋白质紧密地连接到生物电信号，通过离子通道蛋白形成梯度，其转录的下游基因由电压调节，以及转换生物电动状态变化到第二信使级联的转导机械。然而，数据清楚地表明生物电信号是一种无毒的控制层，而不是降低到细胞状态的生物化学或遗传叙述。细胞之间的生物电连通的实时动态不完全通过转录组或蛋白质组学分析完全捕获，并且对于生长和形式的特异性变化的必要和充分的触发可以是生理状态，而潜在的基因基因座可以自由分歧。该激动人心的新字段中的下一步包括开发用于理解非神经生物电网中编码的解剖学语义的新颖概念工具，以及改进的用于读取和写入电气状态信息到体细胞组织中的改进的生物物理工具。裂解生物电码将对发育生物学，再生医学和合成生物工程具有变革影响。

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