...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in lipidology >Plasma lipid transfer proteins.
【24h】

Plasma lipid transfer proteins.

机译：血浆脂质转移蛋白。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: Plasma cholesteryl ester transfer protein and phospholipid transfer protein are involved in lipoprotein metabolism. Conceivably, manipulation of either transfer protein could impact atherosclerosis and other lipid-driven diseases. RECENT FINDINGS: Cholesteryl ester transfer protein mediates direct HDL cholesteryl ester delivery to the liver cells; adipose tissue-specific overexpression of cholesteryl ester transfer protein in mice reduces the plasma HDL cholesterol concentration and adipocyte size; cholesteryl ester transfer protein TaqIB polymorphism is associated with HDL cholesterol plasma levels and the risk of coronary heart disease. In apolipoprotein B transgenic mice, phospholipid transfer protein deficiency enhances reactive oxygen species-dependent degradation of newly synthesized apolipoprotein B via a post-endoplasmic reticulum process, as well as improving the antiinflammatory properties of HDL in mice. Activity of this transfer protein in cerebrospinal fluid of patients with Alzheimer's disease is profoundly decreased and exogenous phospholipid transfer protein induces apolipoprotein E secretion by primary human astrocytes in vitro. SUMMARY: Understanding the relationship between lipid transfer proteins and lipoprotein metabolism is expected to be an important frontier in the search for a therapy for atherosclerosis.
机译：审查目的：血浆胆固醇酯转移蛋白和磷脂转移蛋白参与脂蛋白代谢。可以想象，任何一种转移蛋白的操纵都可能影响动脉粥样硬化和其他脂质驱动的疾病。最近的发现：胆固醇酯转移蛋白介导HDL胆固醇酯直接传递到肝细胞。小鼠胆固醇组织转移蛋白的脂肪组织特异性过表达降低了血浆HDL胆固醇浓度和脂肪细胞大小;胆固醇酯转移蛋白TaqIB多态性与HDL胆固醇血浆水平和冠心病风险有关。在载脂蛋白B转基因小鼠中，磷脂转运蛋白缺乏症通过内质网后过程增强了新合成的载脂蛋白B的依赖于活性氧的降解，并改善了小鼠HDL的抗炎特性。阿尔茨海默氏病患者脑脊液中这种转移蛋白的活性大大降低，外源性磷脂转移蛋白在体外诱导人原代星形胶质细胞分泌载脂蛋白E。概述：理解脂质转移蛋白和脂蛋白代谢之间的关系有望成为寻找动脉粥样硬化疗法的重要前沿。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号