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首页> 外文期刊>Current opinion in lipidology >Immunomodulation of the inflammatory response in atherosclerosis.
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Immunomodulation of the inflammatory response in atherosclerosis.

机译：动脉粥样硬化中炎症反应的免疫调节。

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PURPOSE OF REVIEW: Cardiovascular disease, as manifested in the formation of atherosclerotic lesions, can be described as a chronic inflammatory autoimmune-like disease that proceeds in the context of enhanced plasma lipid levels. Modulation of the immune response may therefore form a valuable therapy in addition to standardized cholesterol and blood pressure-lowering therapies. The purpose of this review is to describe a number of recent approaches to immunomodulate atherosclerosis: immunization against mediators involved in atherosclerosis, such as cytokines and modified low-density lipoprotein; intervention in cytokine pathways; intervention in co-stimulatory pathways; activation of regulatory T cells; and modulation of natural killer T cells. RECENT FINDINGS: The most recent findings point to an important role for regulatory T cells in atherosclerotic lesion formation. The function of the regulatory T cells is modulated by chemokines and by co-stimulatory pathways, whereas the function of these cells can be strongly upregulated by anti-CD3 treatment and tolerance induction. SUMMARY: In the near future the first exponents of this approach, such as immunization and enhancement of the function of regulatory T cells, may enter the first phase of clinical trials, and may ultimately add to the current therapies in atherosclerosis.
机译：审查的目的：动脉粥样硬化病变的形成所表现出的心血管疾病，可以描述为一种慢性炎症性自身免疫性疾病，在血浆脂质水平升高的情况下发生。因此，除了标准化的胆固醇和降压疗法外，免疫应答的调节还可形成有价值的疗法。这篇综述的目的是描述一些免疫调节动脉粥样硬化的新方法：针对与动脉粥样硬化有关的介质，例如细胞因子和修饰的低密度脂蛋白的免疫;干预细胞因子途径;干预共刺激途径;调节性T细胞的活化;和调节自然杀伤T细胞最近的发现：最新发现表明调节性T细胞在动脉粥样硬化病变形成中具有重要作用。调节性T细胞的功能由趋化因子和共刺激途径调节，而这些细胞的功能可通过抗CD3治疗和耐受诱导而强烈上调。概述：在不久的将来，这种方法的第一个指数，例如免疫接种和增强调节性T细胞的功能，可能进入临床试验的第一阶段，并最终可能会增加目前动脉粥样硬化的治疗方法。

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