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首页> 外文期刊>Current opinion in lipidology >LOX-1: A multiligand receptor at the crossroads of response to danger signals
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LOX-1: A multiligand receptor at the crossroads of response to danger signals

机译：LOX-1：一种多配体受体，处于危险信号响应的十字路口

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PURPOSE OF REVIEW: LOX-1 is a multiligand receptor implicated in endothelial dysfunction and atherosclerosis, although it was originally identified as an oxidized LDL receptor. In this review, the roles of various LOX-1 ligands and their interaction with LOX-1 are discussed to understand the pathophysiological significance of LOX-1. RECENT FINDINGS: LOX-1 knockout mice showed resistance of endothelium-dependent vasorelaxation against oxidized LDL and retardation of atherosclerosis progression. LOX-1 ligand reduction in mice also attenuated atherosclerosis progression. In a human cohort study, high concentration of apoB-containing LOX-1 ligands predicted the incidence of cardiovascular disease. Furthermore, modified HDL, which existed in high concentration in the plasma of coronary artery disease patients, was found to induce impairment of endothelial nitric oxide release via LOX-1. In addition to lipoproteins, LOX-1 was found to work as a C-reactive protein receptor providing a scaffold for the activation of the complement system. SUMMARY: LOX-1 is a unique molecule among the sensors of danger signals. LOX-1 is not only sensing danger signals such as modified LDL and heat shock protein, but also scaffolding other danger sensors including C-reactive protein and C1q, and directly commanding responses to danger signals by working as a cell adhesion molecule. Via these functions, LOX-1 might work as a surveillance molecule of vascular homeostasis.
机译：审查目的：LOX-1是一种多配体受体，与内皮功能障碍和动脉粥样硬化有关，尽管它最初被鉴定为氧化的LDL受体。在这篇综述中，讨论了各种LOX-1配体的作用及其与LOX-1的相互作用，以了解LOX-1的病理生理意义。最近的发现：LOX-1基因敲除小鼠表现出对氧化LDL内皮依赖性血管舒张的抵抗力和动脉粥样硬化进程的延迟。小鼠中LOX-1配体的减少也减缓了动脉粥样硬化的进展。在一项人类队列研究中，高浓度的含apoB的LOX-1配体预测了心血管疾病的发生率。此外，发现高浓度存在于冠状动脉疾病患者血浆中的修饰HDL会通过LOX-1诱导内皮一氧化氮释放受损。除了脂蛋白外，还发现LOX-1可以作为C反应蛋白受体，为激活补体系统提供支架。简介：LOX-1是危险信号传感器中的独特分子。 LOX-1不仅可以感应诸如修饰的LDL和热休克蛋白之类的危险信号，而且可以支撑包括C反应蛋白和C1q在内的其他危险传感器，并通过充当细胞粘附分子来直接指挥对危险信号的响应。通过这些功能，LOX-1可能作为血管稳态的监测分子。

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