ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins.

Oram JF; Vaughan AM

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ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins.

机译：ABCA1介导的细胞胆固醇和磷脂向HDL载脂蛋白的转运。

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Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A-I, accumulation of sterol in tissue macrophages, and prevalent atherosclerosis. This implies that lipidation of apolipoprotein A-I by the ABCA1 pathway is required for generating HDL particles and clearing sterol from macrophages. Thus, the ABCA1 pathway has become an important therapeutic target for mobilizing excess cholesterol from tissue macrophages and protecting against atherosclerosis.

机译：贫脂载脂蛋白通过称为ABCA1（以前称为ABC1）的ATP结合盒式转运蛋白控制的主动转运途径去除细胞胆固醇和磷脂。 ABCA1中的突变会导致丹吉尔病，这是一种严重的HDL缺乏症候群，其特征是血浆载脂蛋白A-1的快速更新，组织巨噬细胞中固醇的积累以及普遍的动脉粥样硬化。这意味着通过ABCA1途径使载脂蛋白A-1脂化是产生HDL颗粒和从巨噬细胞清除固醇所必需的。因此，ABCA1途径已经成为从组织巨噬细胞中动员过量胆固醇并预防动脉粥样硬化的重要治疗靶标。

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来源
《Current opinion in lipidology》 |2000年第3期|共8页
作者
Oram JF; Vaughan AM;
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正文语种 eng
中图分类生物化学;
关键词
ABC Transporters; Cholesterol; Lipoproteins; HDL; Phospholipids; ABCA1-protein; ABC转运子; 胆固醇; 脂蛋白类; HDL; 磷脂类;

机译：ABC Transporters;Cholesterol;Lipoproteins;HDL;Phospholipids;ABCA1-protein;ABC转运子;胆固醇;脂蛋白类;HDL;磷脂类;

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专利

1. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. [J] . Oram JF, Vaughan AM Current opinion in lipidology . 2000,第3期

机译：ABCA1介导的细胞胆固醇和磷脂向HDL载脂蛋白的转运。
2. Structural modification of plasma HDL by phospholipids promotes efficient ABCA1-mediated cholesterol release [J] . Hassan HH, Blain S, Boucher B, Journal of Lipid Research . 2005,第7期

机译：磷脂对血浆HDL的结构修饰可促进有效的ABCA1介导的胆固醇释放
3. In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux [J] . Yancey PG., Kawashiri M., Moore R., Journal of Lipid Research . 2004,第2期

机译：HDL磷脂的体内调节对SR-BI-和ABCA1介导的胆固醇流出具有相反的作用
4. Preparation of phospholipid cholesterol ester microemulsionsfor cellular nutrition and drug delivery [C] . Sima Hayavi, Gayle Duncan, GavinHalbert Controlled Release Society 31st annual meeting transactions: abstracts . 2004

机译：磷脂胆固醇酯微乳的制备及其细胞营养和药物传递
5. Effect of a Coconut Oil Supplement (2g/d) on Total Cholesterol to HDL Cholesterol Ratio in Healthy Adults. [D] . Shedden, Rachel. 2017

机译：椰子油补充剂（2g / d）对健康成年人体内总胆固醇与HDL胆固醇之比的影响。
6. Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity Generates New Prebeta-1 HDL and Causes an Increase in HDL Size [O] . Herman J. Kempen, Dorota B. Schranz, Bela F. Asztalos, 2014

机译：将MDCO-216（ApoA-IMilano / POPC）与人血清一起孵育可增强ABCA1介导的胆固醇外流能力产生新的Prebeta-1 HDL并导致HDL大小增加
7. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport [O] . Takashi Kuwano, Xin Bi, Eleonora Cipollari, 2017

机译：磷脂转移蛋白的过度表达和缺失降低了HDL质量和胆固醇的流出能力，但不是巨噬细胞反向胆固醇运输

ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins.

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