Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.

Farese RV Jr; Cases S; Smith SJ

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Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.

机译：甘油三酸酯合成：从二酰基甘油酰基转移酶的克隆中获得的见解。

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Although the biochemistry of triglyceride synthesis has been studied for decades, an understanding of the molecular processes involved has been lacking. The recent cloning of a gene encoding acyl coenzyme A : diacylglycerol acyltransferase, an enzyme that catalyses the final step in triglyceride synthesis, has opened this area to molecular investigation and has begun to provide new insights into triglyceride metabolism.

机译：尽管对甘油三酸酯合成的生物化学进行了数十年的研究，但仍缺乏对涉及的分子过程的了解。最近克隆了一个编码酰基辅酶A的基因：二酰基甘油酰基转移酶，该酶催化甘油三酸酯合成的最后一步，为该领域的分子研究开辟了道路，并已开始提供有关甘油三酸酯代谢的新见解。

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《Current opinion in lipidology》 |2000年第3期|共6页
作者
Farese RV Jr; Cases S; Smith SJ;
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正文语种 eng
中图分类生物化学;
关键词
Acyltransferases; Triglycerides; diacylglycerol O acyltransferase; DNA; Complementary; 酰基转移酶类; 甘油三酯类;

机译：Acyltransferases;Triglycerides;diacylglycerol O acyltransferase;DNA;Complementary;酰基转移酶类;甘油三酯类;

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专利

1. Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. [J] . Farese RV Jr, Cases S, Smith SJ Current opinion in lipidology . 2000,第3期

机译：甘油三酸酯合成：从二酰基甘油酰基转移酶的克隆中获得的见解。
2. New Synthesis of sn-1,2- and sn-2,3-O-Diacylglycerols-Application to the Synthesis of Enantiopure Phosphonates Analogous to Triglycerides: A New Class of Inbhibitors of Lipases [J] . Frank Marguet, Jean-Francois Cavalier, Robert Verger, European journal of organic chemistry . 1999,第7期

机译：sn-1,2-和sn-2,3-O-二酰基甘油的新合成-类似于甘油三酸酯的对映体纯膦酸酯的应用：一类新的脂肪酶抑制剂
3. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice [J] . Gluchowski Nina L., Gabriel Katlyn R., Chitraju Chandramohan, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2019,第6期

机译：肝细胞缺失甘油三酯合成酶酰基CoA：二酰基甘油酰基转移酶2减少脂肪变性而不会增加小鼠的炎症或纤维化
4. INSIGHTS INTO THE STRUCTURE AND function OF ACYL-CoA: DIACYLGLYCEROL ACYLTRANSFERASE [C] . RODRIGO M.P. SILOTO, QIN LIU, RANDALL J. WESELAKE, International Symposium on Biocatalysis and Biotechnology . 2010

机译：酰基 - CoA的结构和功能见解：二酰基甘油酰基转移酶
5. Dietary fiber/carnitine, diacylglycerol, and low glycemic index starch effects on obesity and triglyceride rich lipoprotein metabolism in dogs. [D] . Mitsuhashi, Yuka. 2009

机译：膳食纤维/肉碱，二酰基甘油和低血糖指数淀粉对狗的肥胖和富含甘油三酸酯的脂蛋白代谢的影响。
6. The diacylglycerols dioctanoylglycerol and oleoylacetylglycerol enhance prostaglandin synthesis by inhibition of the lysophosphatide acyltransferase. [O] . M Goppelt-Strübe, H J Pfannkuche, D Gemsa, 1987

机译：二酰基甘油二辛酰基甘油和油酰基乙酰甘油通过抑制溶血磷脂酰基转移酶来增强前列腺素的合成。
7. The diacylglycerols dioctanoylglycerol and oleoylacetylglycerol enhance prostaglandin synthesis by inhibition of the lysophosphatide acyltransferase. [O] . Goppelt-Strübe, M, Pfannkuche, H J, Gemsa, D, 1987

机译：二酰基甘油二辛酰基甘油和油酰基乙酰甘油通过抑制溶血磷脂酰基转移酶来增强前列腺素的合成。

Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.

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