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首页> 外文期刊>Current opinion in lipidology >ATP-binding cassette transporter G1 and lipid homeostasis.
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ATP-binding cassette transporter G1 and lipid homeostasis.

机译：ATP结合盒转运蛋白G1和脂质稳态。

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摘要

PURPOSE OF REVIEW: This review briefly discusses the ATP-binding cassette transporter G (ABCG) family members and emphasizes recent studies that identify ABCG1 as a key regulator of cellular lipid homeostasis. RECENT FINDINGS: The in-vivo importance of ABCG1 has recently been demonstrated with both loss-of-function and gain-of-function studies in mice. Administration of a diet high in both fat and cholesterol to ABCG1 mice results in massive cholesterol accumulation in both the liver and lungs. In contrast, lipid accumulation is greatly attenuated in transgenic mice that express both the murine and human ABCG1 genes. Despite the observed tissue lipid accumulation, plasma lipid levels and lipoprotein cholesterol distribution are not significantly different between wild-type, ABCG1, and hABCG1 transgenic mice. Other studies show that ABCG1 expression is induced following activation of the nuclear receptor LXR and that over expression of ABCG1 results in increased efflux of cellular cholesterol to HDL or phospholipid vesicles. SUMMARY: The ABCG1 transporter plays a key role in regulating cellular cholesterol and lipid homeostasis. Elucidation of the molecular mechanism by which ABCG1 controls sterol flux should provide critical information that may link ABCG1 to the reverse cholesterol transport pathway or diseases such as atherosclerosis.
机译：审查的目的：这项审查简要讨论了ATP结合盒转运蛋白G（ABCG）家庭成员，并强调了最近的研究，这些研究将ABCG1鉴定为细胞脂质稳态的关键调节剂。最近的发现：ABCG1的体内重要性最近在小鼠的功能丧失和功能获得研究中得到了证实。对ABCG1小鼠施用高脂肪和高胆固醇的饮食会导致肝脏和肺部大量胆固醇积聚。相反，在表达鼠和人ABCG1基因的转基因小鼠中，脂质的积累被大大减弱。尽管观察到组织脂质积累，野生型，ABCG1和hABCG1转基因小鼠之间的血浆脂质水平和脂蛋白胆固醇分布没有显着差异。其他研究表明，ABCG1的表达在核受体LXR激活后被诱导，而ABCG1的过度表达导致细胞胆固醇向HDL或磷脂小泡的外排增加。摘要：ABCG1转运蛋白在调节细胞胆固醇和脂质稳态中起关键作用。阐明ABCG1控制固醇通量的分子机制应提供可能将ABCG1与胆固醇反向转运途径或疾病（例如动脉粥样硬化）联系起来的关键信息。

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