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首页> 外文期刊>Current opinion in lipidology >Role of peripheral serotonin in glucose and lipid metabolism.
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Role of peripheral serotonin in glucose and lipid metabolism.

机译：外周血清素在葡萄糖和脂质代谢中的作用。

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PURPOSE OF REVIEW: Two independent serotonin systems exist, one in the brain and the other in the periphery. Serotonin is a well known monoaminergic neurotransmitter in the central nervous system and it is known to regulate feeding behavior, meal size, and body weight. On the other hand, there is much less evidence for the role of serotonin as a gastrointestinal hormone, particularly with respect to its effects on glucose and lipid metabolism. This review summarizes our current understanding of the role of peripheral serotonin on glucose and lipid metabolism and the implications of this for further research. RECENT FINDINGS: The enterochromaffin cells of the gastrointestinal tract produce peripheral serotonin postprandially. In mice, it induces a decrease in the concentration of circulating lipids as well as hyperglycemia and hyperinsulinemia through its action on several serotonin receptors. Further, serotonin metabolites act as endogenous agonists for peroxisome proliferator-activated receptor gamma and serotonin accelerates adipocyte differentiation via serotonin receptor 2A and 2C. Studies of serotonin are likely to provide new insights into the field of lipid accumulation and metabolism. SUMMARY: Recent studies show new physiological functions of peripheral serotonin, linked to glucose and lipid metabolism. Peripheral serotonin may serve as an attractive new therapeutic target for the treatment of metabolic disorders in the near future.
机译：审查目的：存在两个独立的5-羟色胺系统，一个在大脑中，另一个在外围。 5-羟色胺是中枢神经系统中众所周知的单胺能神经递质，已知它能调节喂养行为，进餐量和体重。另一方面，关于5-羟色胺作为胃肠激素的作用的证据很少，特别是关于其对葡萄糖和脂质代谢的影响。这篇综述总结了我们目前对外周血清素对葡萄糖和脂质代谢的作用的理解，以及对进一步研究的意义。最近的发现：胃肠道的肠嗜铬细胞在餐后产生外周血清素。在小鼠中，它通过对几种5-羟色胺受体的作用而引起循环脂质浓度的降低以及高血糖和高胰岛素血症。此外，5-羟色胺代谢产物作为过氧化物酶体增殖物激活的受体γ的内源性激动剂，并且5-羟色胺通过5-羟色胺受体2A和2C促进脂肪细胞分化。血清素的研究可能会为脂质积累和代谢领域提供新的见解。简介：最近的研究表明，外周血清素的新生理功能与葡萄糖和脂质代谢有关。周围血清素可能在不久的将来成为治疗代谢紊乱的有吸引力的新治疗靶标。

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