...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in lipidology >Multiple roles of angiopoietins in atherogenesis.
【24h】

Multiple roles of angiopoietins in atherogenesis.

机译：血管生成素在动脉粥样硬化中的多种作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: The roles of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) during vascular development have been extensively investigated, as has been their role in controlling the responsiveness of the endothelium to exogenous cytokines. However, very little is known about the role of these vascular morphogenic molecules in the pathogenesis of atherosclerosis. Here, we summarize the recent research into angiopoietins in atherosclerosis. RECENT FINDINGS: Angiopoietin-2 is a context-dependent agonist that protects against the development of arteriosclerosis in rat cardiac allograft. A recent study showed, contrary to expectations, that a single systemic administration of adenoviral Ang-2 to apoE mice, fed a Western diet, reduced atherosclerotic lesion size and LDL oxidation in a nitric oxide synthase dependent manner. In contrast, overexpression of Ang-1 fails to protect from rat cardiac allograft due to smooth muscle cell activation. The potential proatherogenic effect of Ang-1 is further supported by the induction of chemotaxis of monocytes by Ang-1 in a manner that is independent of Tie-2 and integrin binding. These studies highlight the need for extensive research to better understand the role of angiopoietins in the cardiovascular setting. SUMMARY: Ang-2 inhibits atherosclerosis by limiting LDL oxidation via stimulation of nitric oxide production. In contrast, Ang-1 can promote monocyte and neutrophil migration. The angiopoietin-Tie-2 system provides an important new target for modulating vascular function.
机译：审查的目的：血管生成素1（Ang-1）和血管生成素2（Ang-2）在血管发育过程中的作用已被广泛研究，它们在控制内皮对外源性细胞因子的反应中也起着重要的作用。然而，关于这些血管形态发生分子在动脉粥样硬化发病机理中的作用了解甚少。在这里，我们总结了对动脉粥样硬化中血管生成素的最新研究。最近的发现：Angiopoietin-2是一种上下文相关的激动剂，可防止大鼠心脏同种异体移植中动脉硬化的发展。与预期相反，最近的一项研究表明，对apoE小鼠进行一次全身性腺病毒Ang-2单一给药，以西方饮食喂养，可以减少一氧化氮合酶依赖性的动脉粥样硬化病变的大小和LDL的氧化。相反，由于平滑肌细胞活化，Ang-1的过表达不能保护免受大鼠心脏同种异体移植物的侵害。 Ang-1以独立于Tie-2和整联蛋白结合的方式诱导单核细胞趋化性进一步支持Ang-1的潜在促动脉粥样硬化作用。这些研究强调需要进行广泛的研究以更好地了解血管生成素在心血管疾病中的作用。摘要：Ang-2通过刺激一氧化氮生成来限制LDL氧化，从而抑制动脉粥样硬化。相反，Ang-1可以促进单核细胞和中性粒细胞迁移。血管生成素-Tie-2系统为调节血管功能提供了重要的新靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号