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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >A matched‐pair analysis reveals marginally reduced CD34+ cell mobilization on second occasion in 27 related donors who underwent peripheral blood stem cell collection twice at the same institution
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A matched‐pair analysis reveals marginally reduced CD34+ cell mobilization on second occasion in 27 related donors who underwent peripheral blood stem cell collection twice at the same institution

机译：匹配对分析显示，在同一机构在同一机构在两次接受外周血干细胞收集的27个相关捐赠者中，略微降低了CD34 +细胞动员。

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BACKGROUND In a small proportion of cases, hematopoietic function is insufficient after allogeneic hematopoietic stem cell transplantation, as a result of poor graft function or graft failure. These complications are common indications of re‐mobilization of the initial donor, either for a second allograft or for an infusion of CD34+ Selected stem Cell Boost (SCB). METHODS AND MATERIALS We retrospectively reviewed the results of two cycles of CD34+ cell mobilization and collection. CD34+ cells mobilized and collected at each cycle were compared. When CD34+ cell selection from the collected allogeneic mononuclear cells was indicated, it was performed with the Clinimacs Plus? medical device, and results from in‐process and final quality checks were analyzed. To assess the efficacy of CD34+ SCB, transfusion needs before and after the infusion of selected CD34+ cells were calculated. RESULTS The median peripheral blood concentration of CD34+ cells/μL was marginally reduced during the second cycle (35.6 vs 33.8, p??0.05); results revealed a strong correlation between paired values (r = 0.85). The cumulative number of collected CD34+ cells were similar for both cycles; the total processed blood volume was higher during the second cycle (p = 0.023). For CD34+ immune‐selection procedures, CD34+ cell recovery and purity were respectively 57% and 95%, with a median T‐cell depletion of 6.7 log. Recipients' needs for platelet and red blood cell transfusions were significantly reduced after CD34+ SCB. CONCLUSION This study confirms the feasibility of a second cycle of mobilization in healthy related donors and the benefits of CD34+ SCB on hematopoietic reconstitution.
机译：背景技术在一小部分病例中，由于移植物差或移植物失效，同种异体造血干细胞移植后造血功能不足。这些并发症是重新调动初始供体的常见指示，用于第二同种异体移植物或输注CD34 +选定的干细胞增强（SCB）。方法和材料我们回顾性地审查了两种CD34 +细胞动员和收集的循环结果。比较了在每个循环中动员和收集的CD34 +细胞。当指示来自收集的同种异体单核细胞的CD34 +细胞选择时，用Clinimacs加上进行吗？分析了医疗器械，以及过程中的结果和最终质量检查。为了评估CD34 + SCB的功效，计算出在输注选定的CD34 +细胞之前和之后的输血需要。结果在第二个循环期间CD34 +细胞/μl的中位外周血浓度略微降低（35.6 Vs 33.8，p≤0.05）;结果显示成对值之间的相关性强（R = 0.85）。每个循环相似收集的CD34 +细胞的累积次数;在第二个循环期间，总处理的血容量较高（P = 0.023）。对于CD34 +免疫选择程序，CD34 +细胞回收和纯度分别为57％和95％，中值T细胞耗尽6.7原木。在CD34 + SCB后，接受者对血小板和红细胞输血的需求显着降低。结论本研究证实了第二次动员循环在健康相关捐赠者中的可行性以及CD34 + SCB对造血重建的益处。

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