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首页> 外文期刊>Current opinion in HIV and AIDS >Th17 cell dynamics in HIV infection.
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Th17 cell dynamics in HIV infection.

机译：HIV感染中的Th17细胞动力学。

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PURPOSE OF REVIEW: Th17 cells are a newly identified subtype of CD4 T cells that respond to bacterial and fungal antigens and are important in mucosal immunology. Because HIV infection results in loss of CD4 T cells as well as disruption to the gastrointestinal tract that causes microbial translocation and immune activation, Th17 cells potentially play an important role in HIV pathogenesis. Here we examine the relationship between Th17 cells and HIV disease pathogenesis. RECENT FINDINGS: Th17 cells are preferentially lost from the gastrointestinal tract of HIV-infected individuals, which is not entirely due to direct infection, as Th17 cells can be infected in vivo, but are not preferentially infected. Long-term highly active antiretroviral therapy (HAART) can result in restoration of Th17 cells in the gastrointestinal, which may be associated with better disease prognosis. Furthermore, other cells, such as Vdelta1 T cells, can make IL-17 in vivo during HIV infection and may contribute to antibacterial immunity after loss of Th17 cells. SUMMARY: Recent studies have improved our understanding of the role for Th17 cells during HIV infection; however, more studies are needed to discern better the detrimental consequences of loss of Th17 cells during HIV infection.
机译：审查目的：Th17细胞是CD4 T细胞的一种新鉴定的亚型，对细菌和真菌抗原有反应，并且在粘膜免疫学中很重要。由于HIV感染会导致CD4 T细胞丢失以及导致微生物移位和免疫激活的胃肠道中断，因此Th17细胞可能在HIV发病机理中发挥重要作用。在这里，我们检查了Th17细胞与HI​​V疾病发病机制之间的关系。最近的发现：Th17细胞优先从HIV感染者的胃肠道中丢失，这并不完全是直接感染，因为Th17细胞可以在体内被感染，但并不被优先感染。长期高活性抗逆转录病毒疗法（HAART）可以导致胃肠道Th17细胞恢复，这可能与更好的疾病预后相关。此外，其他细胞（例如Vdelta1 T细胞）可以在HIV感染期间在体内产生IL-17，并且在Th17细胞丢失后可能有助于抗菌免疫。简介：最近的研究提高了我们对Th17细胞在HIV感染过程中的作用的了解。然而，需要更多的研究来更好地识别HIV感染期间Th17细胞丢失的有害后果。

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