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首页> 外文期刊>Current opinion in lipidology >Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis.
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Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis.

机译：磷脂酰胆碱生物合成在调节脂蛋白稳态中的作用。

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摘要

PURPOSE OF REVIEW: This review summarizes the role of phosphatidylcholine metabolism in plasma lipoprotein homeostasis. RECENT FINDINGS: While it was previously known that phosphatidylcholine biosynthesis was required for normal hepatic VLDL secretion, recent studies have shown that both phosphatidylcholine biosynthetic pathways (the cytidine 5'-diphosphocholine and the phosphatidylethanolamine methylation pathways) are required. In addition, a requirement of acyl-coenzyme A synthetase 3, but not acyl-coenzyme A synthetase 1 or 4, for phosphatidylcholine synthesis and VLDL secretion is now documented. ABCA1 has been implicated in the transfer of phosphatidylcholine to apolipoproteinA-1 both during and after secretion of apolipoproteinA-1. Other studies have introduced the concept of reverse phosphatidylcholine transport in which both HDL and LDL supply phosphatidylcholine to the liver. An unexpected finding is that half of the phosphatidylcholine delivered to liver from lipoproteins is converted into triacylglycerol. SUMMARY: The liver is both a donor of phosphatidylcholine during the assembly and secretion of lipoproteins as well as a recipient of phosphatidylcholine from plasma lipoproteins.
机译：审查的目的：这篇综述总结了磷脂酰胆碱代谢在血浆脂蛋白稳态中的作用。最近的发现：虽然以前知道正常的肝VLDL分泌需要磷脂酰胆碱的生物合成，但最近的研究表明，磷脂酰胆碱的生物合成途径（胞苷5'-二磷酸胆碱和磷脂酰乙醇胺甲基化途径）都是必需的。另外，现已证明，对于磷脂酰胆碱合成和VLDL分泌，需要酰基辅酶A合成酶3，而不是酰基辅酶A合成酶1或4。在分泌载脂蛋白A-1的过程中和分泌后，ABCA1都与磷脂酰胆碱向载脂蛋白A-1的转移有关。其他研究也引入了反向磷脂酰胆碱转运的概念，其中HDL和LDL均向肝脏供应磷脂酰胆碱。一个出乎意料的发现是，从脂蛋白输送到肝脏的磷脂酰胆碱的一半被转化为三酰甘油。摘要：肝脏既是脂蛋白组装和分泌过程中的磷脂酰胆碱的供体，也是血浆脂蛋白中磷脂酰胆碱的受体。

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