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首页> 外文期刊>Current opinion in lipidology >Effect of heme oxygenase-1 on vascular function and disease.
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Effect of heme oxygenase-1 on vascular function and disease.

机译：血红素加氧酶-1对血管功能和疾病的影响。

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PURPOSE OF REVIEW: Heme oxygenase-1 apart from converting heme to carbon monoxide, iron and biliverdin has been shown to exert anti-inflammatory, antiapoptotic and antioxidant actions. The present review summarizes the most recent studies about heme oxygenase-1 involvement in atherosclerosis, neovascularization and endothelial progenitor cells biology. RECENT FINDINGS: Heme oxygenase-1 has been shown to be protective against atherosclerosis via decreasing ROS generation and proinflammatory cytokine production resulting in diminished lipid uptake and foam cell formation. Moreover, heme oxygenase-1 role in neovascularization and its involvement in response of endothelial progenitor cells to stromal cell derived factor-1 as well as endothelial cells to vascular endothelial growth factor has been stressed, recently. The detailed mechanisms of heme oxygenase-1 action in the processes of vasculogenesis and angiogenesis as well as the involvement of Nrf2 and KLF2 transcription factors in heme oxygenase-1-dependent vascular protection are among the subjects most intensively studied, currently. SUMMARY: Recent studies underscore the critical role of heme oxygenase-1 in neovascularization, implicating heme oxygenase-1 as an attractive therapeutic target for treatment of cardiovascular disease.
机译：审查目的：血红素加氧酶-1除了将血红素转化为一氧化碳外，还显示出铁和胆绿素具有抗炎，抗凋亡和抗氧化作用。本综述总结了有关血红素加氧酶-1参与动脉粥样硬化，新血管形成和内皮祖细胞生物学的最新研究。最近的发现：血红素加氧酶-1通过减少ROS的产生和促炎性细胞因子的产生，从而减少脂质的摄取和泡沫细胞的形成，对动脉粥样硬化具有保护作用。此外，近来已强调了血红素加氧酶-1在新血管形成中的作用及其参与内皮祖细胞对基质细胞衍生因子-1以及内皮细胞对血管内皮生长因子的应答。目前，对血红素加氧酶-1在血管生成和血管生成过程中作用的详细机制以及Nrf2和KLF2转录因子参与血红素加氧酶-1依赖性血管保护的研究是目前研究最深入的主题。简介：最近的研究强调了血红素加氧酶-1在新血管形成中的关键作用，暗示血红素加氧酶-1是治疗心血管疾病的有吸引力的治疗靶标。

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