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首页> 外文期刊>Current opinion in lipidology >Sortilin and lipoprotein metabolism: making sense out of complexity
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Sortilin and lipoprotein metabolism: making sense out of complexity

机译：排序蛋白和脂蛋白代谢：出于复杂性的考虑

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Purpose of review:Genome-wide association studies have been used as an unbiased tool to identify novel genes that contribute to variations in LDL cholesterol levels in the hopes of uncovering new biology and new therapeutic targets for the treatment of atherosclerotic cardiovascular disease. The locus identified by genome-wide association studies with the strongest association with LDL cholesterol and atherosclerotic cardiovascular disease is the 1 p 13 sortilin-1 (SORT1) locus. Here, we review the identification and characterization of this locus, the initial physiological studies describing the role of SORT1 in lipoprotein metabolism, and recent work that has begun to sort out the complexity of this role.Recent findings:Studies by several groups support an important role for sortilin in lipoprotein metabolism; however, the directionality of the effect of sortilin on plasma cholesterol and its role in the secretion of hepatic lipoproteins remains controversial. Studies by several groups support a role for sortilin in inhibiting lipoprotein export, whereas other studies suggest that sortilin facilitates lipoprotein export.Summary:Understanding the mechanism by which sortilin affects LDL cholesterol will increase our understanding of the regulation of lipoprotein metabolism and hepatic lipoprotein export and may also allow us to harness the power of the 1 p13 SORT1 locus for the treatment of atherosclerotic cardiovascular disease.
机译：审查目的：全基因组关联研究已被用作鉴定有助于LDL胆固醇水平变化的新基因的无偏工具，以期希望找到治疗动脉粥样硬化性心血管疾病的新生物学和新治疗靶标。通过全基因组关联研究确定的与LDL胆固醇和动脉粥样硬化性心血管疾病最强关联的基因座是1 p 13 sortilin-1（SORT1）基因座。在这里，我们回顾了该基因座的鉴定和表征，描述SORT1在脂蛋白代谢中作用的初步生理学研究以及最近开始弄清该作用复杂性的最新研究。 sortilin在脂蛋白代谢中的作用;然而，sortilin对血浆胆固醇的作用及其在肝脂蛋白分泌中的作用仍然存在争议。几个小组的研究支持sortilin在抑制脂蛋白输出中的作用，而其他研究则表明sortilin促进脂蛋白的输出。也可能使我们能够利用1 p13 SORT1基因座的力量来治疗动脉粥样硬化性心血管疾病。

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