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首页> 外文期刊>Current opinion in lipidology >Clinical utility of serum markers of cholesterol absorption and synthesis
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Clinical utility of serum markers of cholesterol absorption and synthesis

机译：血清胆固醇吸收和合成标志物的临床应用

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PURPOSE OF REVIEW: The serum noncholesterol sterols are widely used today in clinical lipid research as surrogate markers of cholesterol absorption and synthesis. Their applicability and some aspects related to their analysis, use, and interpretations are discussed. RECENT FINDINGS: The serum markers of cholesterol metabolism have been carefully validated in several populations and during different interventions. If the homeostasis between cholesterol absorption and synthesis is lost, the markers cannot be used as surrogates. The markers have been applied in large population and cohort studies to find out how cholesterol metabolism is related to coronary artery disease. Most of the large studies suggested that increased levels of the markers of cholesterol absorption may conceivably be a risk factor for coronary artery disease. SUMMARY: Results even from large population studies vary from population to population. The large number of factors, which interfere with cholesterol metabolism, such as age, sex, BMI, diet, health status, medication, and genetic background, and differences in the analysis methods of the serum markers should be taken into consideration when interpreting the data.
机译：审查目的：血清非胆固醇固醇今天在临床脂质研究中被广泛用作胆固醇吸收和合成的替代标志物。讨论了它们的适用性以及与它们的分析，使用和解释有关的某些方面。最新发现：胆固醇代谢的血清标志物已在多个人群中以及在不同干预措施中得到了仔细验证。如果失去了胆固醇吸收和合成之间的稳态平衡，则这些标记物不能用作替代物。该标志物已用于大量人群和队列研究中，以发现胆固醇代谢与冠状动脉疾病之间的关系。大多数大型研究表明，胆固醇吸收标记物水平升高可能是冠心病的危险因素。摘要：即使从大量人口研究中得出的结果，也因人口而异。年龄，性别，BMI，饮食，健康状况，药物治疗和遗传背景等会影响胆固醇代谢的因素很多，在解释数据时应考虑血清标志物分析方法的差异。 。

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