Inhibition of ApoCIII: the next PCSK9?

Sophie J Bernelot Moens; Julian C van Capelleveen; Erik S G Stroes

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Inhibition of ApoCIII: the next PCSK9?

机译：抑制ApoCIII：下一个PCSK9？

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The central role of apoCIII in hypertriglyceridemia and cardiovascular disease was further cemented by recent findings and promising intervention data that showed the possibility of using antisense therapy to lower apoCIII and triglyceride levels. Currently, planned phase 3 trials should provide answers in regards to long-term efficacy and safety of this novel therapy.

机译：最近的发现和有前途的干预数据进一步证明了apoCIII在高甘油三酸酯血症和心血管疾病中的核心作用，表明使用反义疗法降低apoCIII和甘油三酸酯水平的可能性。目前，计划中的3期试验应就这种新疗法的长期疗效和安全性提供答案。

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《Current opinion in lipidology》 |2014年第6期|共5页
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Sophie J Bernelot Moens; Julian C van Capelleveen; Erik S G Stroes;
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中图分类生物化学;
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1. Inhibition of ApoCIII: the next PCSK9? [J] . Sophie J Bernelot Moens, Julian C van Capelleveen, Erik S G Stroes Current opinion in lipidology . 2014,第6期

机译：抑制ApoCIII：下一个PCSK9？
2. A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice [J] . RachidEssalmani, ElodieWeider, JadwigaMarcinkiewicz, Biological chemistry . 2018,第12期

机译：针对Cys-and His的PCSK9和Evolocumab的单一结构域抗体在人源化PCSK9小鼠中表现出不同的抑制机制
3. Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors: Shaping the future after the further cardiovascular outcomes research with PCSK9 inhibition in subjects with elevated risk (FOURIER) trial [J] . Niki Katsiki, Vasilios G. Athyros, Dimitri P. Mikhailidis, Metabolism: Clinical and Experimental . 2017,第期

机译：ProProtein转化酶枯草杆菌蛋白酶蛋白酶-Kexin型9（PCSK9）抑制剂：在进一步的心血管结果与PCSK9抑制升高风险（傅里叶）试验中的抑制后塑造未来
4. A data-independent acquisition strategy on the Q Exactive for monitoring GALNT2-mediated APOCIII glycosylation in cell culture [C] . Iwao Yamada, Hideo Yoshida, Sasha Singh, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：关于Q的数据无关的采集策略，用于监测细胞培养中GalnT2介导的GalnT2介导的Apociii糖基化
5. Study of the human apolipoprotein CIII (apoCIII) gene and the human apolipoprotein E (apoE) protein. [D] . Lavrentiadou, Sophia N. 1999

机译：人类载脂蛋白CIII（apoCIII）基因和人类载脂蛋白E（apoE）蛋白的研究。
6. Mdm2 is a Novel Activator of ApoCIII Promoter Which is Antagonized by p53 and SHP Inhibition [O] . Zhihong Yang, Yuxia Zhang, Li Wang -1

机译：MDM2是ApociII启动子的新型活化剂其被P53和SHP抑制拮抗
7. Correction to: Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition: A Genome-Wide Association Study and Mendelian Randomization Study in the HUNT, Norway [O] . 2019

机译：校正至：血清PCSK9（Proprotein转化酶枯草杆菌素/ kexin型9），心血管疾病风险以及对PCSK9抑制潜在意外效果的调查：挪威亨特基因组关联研究和孟德利安随机化研究

Inhibition of ApoCIII: the next PCSK9?

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