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首页> 外文期刊>Current opinion in lipidology >The influence of major dietary fatty acids on insulin secretion and action.
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The influence of major dietary fatty acids on insulin secretion and action.

机译：主要饮食脂肪酸对胰岛素分泌和作用的影响。

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PURPOSE OF REVIEW: To briefly summarize recent advances towards understanding the influence of major dietary fatty acids on beta-cell function and evaluate their implications for insulin resistance. RECENT FINDINGS: Studies in humans have shown that beta-cell function and insulin sensitivity improve progressively in the postprandial period as the proportion of monounsaturated fatty acids (MUFAs) with respect to saturated fatty acids (SFAs) in dietary fats increases. However, cell-culture experiments have revealed a dichotomy in the ability of fatty acids to moderate hyperactivity of, and induce lipotoxicity in, beta-cells. There are also some novel findings regarding the ability of HDL to protect beta-cells against oxidized LDL-induced apoptosis in vitro and of reconstituted HDL to attenuate insulin resistance in vivo. These findings raise new questions regarding the contribution of dietary fatty acids to insulin secretion and action. SUMMARY: These new findings point to a critical role for major dietary fatty acids in the etiology and pathogenesis of diabetes, which appears to be of particular relevance during postprandial periods and mainly depends on the fatty acid type. This underscores the importance of dietary fatty acids in standard diabetes management.
机译：审查目的：简要概述了解主要饮食脂肪酸对β细胞功能的影响的最新进展，并评估其对胰岛素抵抗的影响。最近的发现：人体研究表明，随着餐后脂肪中单不饱和脂肪酸（MUFA）相对于饱和脂肪酸（SFA）的比例增加，β细胞功能和胰岛素敏感性在餐后逐渐改善。然而，细胞培养实验已经揭示了脂肪酸调节β细胞过度活跃并诱导其脂毒性的能力的二分法。关于HDL在体外保护β细胞免受氧化的LDL诱导的细胞凋亡以及在体内重构的HDL减弱胰岛素抵抗的能力，也有一些新发现。这些发现提出了有关饮食脂肪酸对胰岛素分泌和作用的新质疑。摘要：这些新发现表明，主要饮食脂肪酸在糖尿病的病因和发病机制中起着至关重要的作用，这在餐后时期似乎特别重要，并且主要取决于脂肪酸的类型。这强调了饮食脂肪酸在标准糖尿病管理中的重要性。

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