Variability OF HIV-1 V2 env domain for integrin binding: Clinical correlates

Fabrizio Claudia; Bavaro Davide F.; Scudeller Luigia; Lepore Luciana; Balena Flavia; Lagioia Antonella; Angarano Gioacchino; Monno Laura; Saracino Annalisa

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Variability OF HIV-1 V2 env domain for integrin binding: Clinical correlates

机译：联合素结合的HIV-1 V2 ENV结构域的变异性：临床相关性

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摘要

The HIV V2(179-181) (HXB2 numbering) tripeptide mediates binding to alpha 4 beta 7 integrin, which is responsible for GALT homing. Our study aimed to assess V2 variability in naive HIV-1 infected patients and its association with clinical and viro-immunological features.

机译：HIV V2（179-181）（HXB2编号）三肽介导与α4β7整联蛋白的结合，这负责GALT归巢。我们的研究旨在评估Naive HIV-1感染患者的V2变异性及其与临床和病毒免疫学特征的关系。

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《Virology》 |2019年第2019期|共6页
作者
Fabrizio Claudia; Bavaro Davide F.; Scudeller Luigia; Lepore Luciana; Balena Flavia; Lagioia Antonella; Angarano Gioacchino; Monno Laura; Saracino Annalisa;
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作者单位

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

IRCCS San Matteo Fdn Clin Epidemiol Unit Sci Direct Viale Camillo Golgi 19 I-27100 Pavia Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

Univ Bari Univ Hosp Policlin Clin Infect Dis Piazza Giulio Cesare 11 I-70124 Bari Italy;

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原文格式 PDF
正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
HIV-1; Gp-120; V2 tripeptide; alpha 4 beta 7; Integrins;

机译：HIV-1;GP-120;v2三肽;alpha 4 beta 7;整合蛋白;

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专利

1. Variability OF HIV-1 V2 env domain for integrin binding: Clinical correlates [J] . Fabrizio Claudia, Bavaro Davide F., Scudeller Luigia, Virology . 2019,第期

机译：联合素结合的HIV-1 V2 ENV结构域的变异性：临床相关性
2. Specific sequences commonly found in the V3 domain of HIV-1 subtype C isolates affect the overall conformation of native Env and induce a neutralization-resistant phenotype independent of VI/V2 masking [J] . Aidy Salomon, Chavdar Krachmarov, Zhong Lai, Virology . 2014,第1期

机译：通常在HIV-1亚型C分离株的V3域中发现的特定序列会影响天然Env的整体构象，并诱导独立于VI / V2掩蔽的抗中和性表型
3. Deglycosylation or partial removal of HIV-1 CN54 gp140 V1/V2 domain enhances env-specific T cells. [J] . Wan Y, Liu L, Wu L AIDS Research and Human Retroviruses . 2009,第6期

机译：HIV-1 CN54 gp140 V1 / V2结构域的去糖基化或部分去除可增强env特异性T细胞。
4. Interaction Between gp120 and Ligand in HIV-1 Env Protein: Molecular Dynamics Simulations and Binding Free Energy Calculations [C] . Vishnudatt Pandey, Gargi Tiwari, Vijaya Shri Mall, International Conference on Advances in Basic Sciences . 2019

机译：HIV-1 ENV蛋白质中GP120与配体之间的相互作用：分子动力学模拟和绑定自由能计算
5. HIV-1 env: Impacting HIV-1 fitness, entry inhibitor drug sensitivity, and in vivo selection of a resistant virus to the microbicide PSC-RANTES. [D] . Dudley, Dawn M. 2008

机译：HIV-1 env：影响HIV-1的适应性，进入抑制剂的药物敏感性以及对杀微生物剂PSC-RANTES的抗性病毒的体内选择。
6. Vaccine-Induced Env V1–V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination [O] . Nicole L. Yates, Hua-Xin Liao, Youyi Fong, -1

机译：疫苗诱导的Env V1-V2 IgG3与较低的HIV-1感染风险相关并在接种疫苗后不久下降
7. Patterns of Amino Acid Variability in NSI-like and SI-like V3 Sequences and a Linked Change in the CD4-Binding Domain of the HIV-1 Env Protein [O] . Milich Lynn, Margolin Barry H., Swanstrom Ronald 1997

机译：NSI样和SI样V3序列中氨基酸变异性的模式以及HIV-1 Env蛋白的CD4结合域的链接变化。

Variability OF HIV-1 V2 env domain for integrin binding: Clinical correlates

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