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首页> 外文期刊>Current opinion in lipidology >The effects of alpha-tocopherol on critical cells in atherogenesis.
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The effects of alpha-tocopherol on critical cells in atherogenesis.

机译：α-生育酚对动脉粥样硬化中关键细胞的作用。

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Low levels of alpha tocopherol have been associated with increased risk for coronary artery disease and increased intake has been shown to be protective. Data support a proatherogenic role for oxidized LDL in atherosclerosis and several studies show that alpha tocopherol decreases the susceptibility of LDL to oxidation. In addition, alpha tocopherol can partition in the artery wall in critical cells such as smooth muscle cells, monocyte-macrophages, endothelial cells, and platelets, exerting beneficial effects. In this review, the anti-atherogenic effects of alpha tocopherol on crucial cells in atherogenesis have been highlighted, such as the inhibition of smooth muscle cell proliferation, preservation of endothelial function, inhibition of monocyte-endothelial adhesion, inhibition of monocyte reactive oxygen species and cytokine release, and inhibition of platelet adhesion and aggregation.
机译：低水平的α-生育酚与冠状动脉疾病的风险增加有关，并且摄入增加已被证明具有保护作用。数据支持了氧化的LDL在动脉粥样硬化中的致动脉粥样硬化作用，一些研究表明，α-生育酚降低了LDL对氧化的敏感性。另外，α-生育酚可以在动脉壁中在诸如平滑肌细胞，单核巨噬细胞，内皮细胞和血小板的关键细胞中分配，发挥有益的作用。在这篇综述中，α生育酚对动脉粥样硬化中关键细胞的抗动脉粥样硬化作用得到了强调，例如抑制平滑肌细胞增殖，保留内皮功能，抑制单核细胞-内皮粘附，抑制单核细胞活性氧和细胞因子释放，并抑制血小板粘附和聚集。

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