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首页> 外文期刊>Current opinion in lipidology >An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity.
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An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity.

机译：visfatin / B前细胞集落增强因子的更新，这是一种普遍存在的，在肥胖症中受到调节的假性细胞因子。

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PURPOSE OF REVIEW: The aim of this article is to summarize all of the recent studies on pre-B cell colony-enhancing factor visfatin, a ubiquitously expressed secreted protein that has been implicated in obesity and insulin resistance. Although pre-B-cell colony-enhancing factor was discovered over 10 years ago, there are many remaining questions about the regulation and function of this protein. RECENT FINDINGS: Studies in the last decade have revealed the endocrine properties of fat cells. One of the most recent proteins shown to be highly expressed in adipose tissue is visfatin, originally identified as pre-B-cell colony-enhancing factor. Visfatin/pre-B-cell colony-enhancing factor appears to be preferentially produced by the visceral adipose tissue and has insulin mimetic actions. Studies by many groups indicate that obesity-related diabetes and accompanying metabolic disorders in humans have been specifically linked to increased visceral adipose tissue mass. The different roles of various adipocytedepots, however, are still poorly understood. It has been hypothesized that understanding the differences in the biology of visceral and subcutaneous human adipose tissue may hold the key to therapeutic strategies aimed at reducing obesity-induced insulin resistance and alleviating symptoms of the metabolic syndrome. Interestingly, some observed actions of visfatin indicate that this secreted protein may be an interesting therapeutic target. Several recent studies, however, indicate that our understanding of visfatin is still speculative. SUMMARY: This review summarizes all of the papers in the last year on the expression and function of visfatin/pre-B-cell colony-enhancing factor and highlights inconsistent observations from various investigators studying this protein. It also highlights previous observations on the role of pre-B-cell colony-enhancing factor. We suggest that the pathophysiologic role of visfatin/pre-B-cell colony-enhancing factor in humans remains largely unknown.
机译：审查目的：本文的目的是总结所有有关B前细胞集落增强因子visfatin的最新研究，visfatin是一种普遍表达的分泌蛋白，与肥胖和胰岛素抵抗有关。尽管十多年前就发现了前B细胞集落增强因子，但有关该蛋白的调控和功能仍有许多疑问。最近的发现：过去十年的研究表明，脂肪细胞的内分泌特性。被证明在脂肪组织中高表达的最新蛋白质之一是visfatin，最初被鉴定为B细胞前集落增强因子。 Visfatin / B细胞前集落增强因子似乎优先由内脏脂肪组织产生，并具有胰岛素模拟作用。许多小组的研究表明，与肥胖相关的糖尿病和人类伴随的代谢异常与内脏脂肪组织量的增加有明确的联系。然而，各种脂肪细胞贮库的不同作用仍然知之甚少。据推测，了解内脏和皮下人类脂肪组织的生物学差异可能是旨在降低肥胖引起的胰岛素抵抗和缓解代谢综合征症状的治疗策略的关键。有趣的是，观察到的visfatin作用表明该分泌的蛋白质可能是有趣的治疗靶标。然而，最近的一些研究表明，我们对维斯汀的理解仍是推测性的。总结：这篇综述总结了去年关于visfatin / B细胞前集落增强因子的表达和功能的所有论文，并强调了研究这种蛋白的不同研究者的不一致观察。它还强调了以前对B细胞集落增强因子作用的观察。我们建议在人类中visfatin / B细胞前集落增强因子的病理生理作用仍然未知。

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