Metabolism of oxidized LDL by macrophages.

Jessup W; Kritharides L

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Metabolism of oxidized LDL by macrophages.

机译：巨噬细胞对氧化的低密度脂蛋白的代谢。

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Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on the metabolism of oxidized LDL by macrophages, and the types, amounts and location of oxidation products that accumulate in these cells. Comparable studies of lesion lipoproteins and foam cells indicate that limited extracellular lipoprotein oxidation, perhaps followed by more extensive intracellular oxidation subsequent to uptake by macrophages, is a more likely scenario in vivo.

机译：在动脉粥样硬化斑块和巨噬细胞泡沫细胞中发现了脂质和蛋白质的氧化产物。巨噬细胞在体外被氧化的LDL吞噬并吞噬了固醇。有什么证据表明这种过程参与了体内泡沫细胞的形成？本综述调查了有关巨噬细胞氧化的LDL代谢的最新知识，以及在这些细胞中积累的氧化产物的类型，数量和位置。对病灶脂蛋白和泡沫细胞的可比研究表明，有限的细胞外脂蛋白氧化，在体内可能是巨噬细胞摄取之后可能发生的更广泛的细胞内氧化。

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《Current opinion in lipidology》 |2000年第5期|共9页
作者
Jessup W; Kritharides L;
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正文语种 eng
中图分类生物化学;
关键词
Lipoproteins; LDL; Macrophages; oxidized low density lipoprotein; 脂蛋白类; LDL; 巨噬细胞;

机译：Lipoproteins;LDL;Macrophages;oxidized low density lipoprotein;脂蛋白类;LDL;巨噬细胞;

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1. Metabolism of oxidized LDL by macrophages. [J] . Jessup W, Kritharides L Current opinion in lipidology . 2000,第5期

机译：巨噬细胞对氧化的低密度脂蛋白的代谢。
2. Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages. [J] . Jadeja RN, Thounaojam MC, Devkar RV, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2011,第6期

机译：Clerodendron glandulosum.Coleb提取物可防止体外人LDL氧化和氧化LDL诱导人单核细胞衍生巨噬细胞凋亡。
3. The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages. [J] . Hao MX, Jiang LS, Fang NY, Journal of Lipid Research . 2010,第8期

机译：大麻素WIN55,212-2可防止小鼠巨噬细胞中氧化的LDL诱导的炎症反应。
4. Transport And Metabolism Of LDL In The Rabbit Aorta Wall In Vivo: A Role For The LDL Receptor? [C] . Morris E.D., Saidel G.M., Chisolm G.M. Engineering in Medicine and Biology Society, 1990., Proceedings of the Twelfth Annual International Conference of the IEEE . 1990

机译：兔主动脉壁中LDL的运输和代谢：LDL受体的作用？
5. LDL receptor and macrophage scavenger receptor regulation by immune complexes containing native or modified LDL in THP-1 macrophages. [D] . Ghosh, Malabika Jagadish. 1997

机译：通过THP-1巨噬细胞中含有天然或修饰LDL的免疫复合物调节LDL受体和巨噬细胞清除剂受体。
6. Oxidized LDL Disrupts Metabolism and Inhibits Macrophage Survival by Activating a miR-9/Drp1/Mitochondrial Fission Signaling Pathway [O] . Ting Xin, Chengzhi Lu, Jing Zhang, 2020

机译：通过激活miR-9 / DRP1 /线粒体裂变信号通路来氧化LDL破坏代谢并抑制巨噬细胞存活
7. Mouse CD36 Has Opposite Effects on LDL and Oxidized LDL Metabolism In Vivo [O] . Vilayphone Luangrath, Mathieu R. Brodeur, David Rhainds, 2008

机译：小鼠CD36对LDL和氧化LDL代谢的影响相反
8. Oxidized LDL Density Lipoprotein Antibodies and Oxidized Low Density Lipoprotein-Containing Immune Complexes: Characteristics and Pathogenic Significance in Diabetes [R] . Atchley, D. H. 2002

机译：氧化LDL密度脂蛋白抗体和含氧化低密度脂蛋白的免疫复合物：糖尿病的特征和致病意义

Metabolism of oxidized LDL by macrophages.

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