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首页> 外文期刊>Current opinion in lipidology >Metabolic effects of thia fatty acids.
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Metabolic effects of thia fatty acids.

机译：硫杂脂肪酸的代谢作用。

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摘要

Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic acid include mitochondrial proliferation, increased catabolism of fatty acids, antiadiposity, improvement in insulin sensitivity, antioxidant properties, reduced proliferation and induction of apoptosis in rapidly proliferating cells, cell differentiation and antiinflammatory action. These biological responses indicate that tetradecylthioacetic acid changes the plasma profile from atherogenic to cardioprotective. As a pan-peroxisome proliferator-activated receptor ligand, tetradecylthioacetic acid regulates the adipose tissue mass and the expression of lipid metabolizing enzymes, particularly those involved in catabolic pathways. In contrast, circumstantial evidences suggest that peroxisome proliferator-activated receptor-independent metabolic pathways may be of importance for the antioxidant, antiproliferative and antiinflammatory action of tetradecylthioacetic acid.
机译：硫杂取代的脂肪酸是饱和脂肪酸，其通过在碳主链的特定位置插入硫原子而被修饰。在最近几年中，已经揭示了3-硫代脂肪酸十四烷基硫代乙酸的多效性作用。对十四烷基硫代乙酸的生物学反应包括线粒体增殖，脂肪酸分解代谢增加，抗肥胖症，胰岛素敏感性改善，抗氧化特性，快速增殖细胞中增殖减少和凋亡诱导，细胞分化和抗炎作用。这些生物学反应表明十四烷基硫代乙酸将血浆谱从动脉粥样硬化变为心脏保护。作为泛过氧化物酶体增殖物激活的受体配体，十四烷基硫代乙酸调节脂肪组织的质量和脂质代谢酶的表达，特别是那些参与分解代谢途径的酶。相反，间接证据表明，过氧化物酶体增殖物激活的受体非依赖性代谢途径对于十四烷基硫代乙酸的抗氧化，抗增殖和抗炎作用可能很重要。

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