Detailed Analyses of the Antifibrotic effects of INT-767, a dual FXR/TGR5 agonist, in an obese mouse model of diet-induced and biopsy-confirmed NASH

Veidal Sanne Skovgaard; Feigh Michael; Hansen Henrik B.; Jelsing Jacob; Vrang Niels; Petitjean Matthieu; Chen Li; Young Mark; Roth Jonathan D.

首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Detailed Analyses of the Antifibrotic effects of INT-767, a dual FXR/TGR5 agonist, in an obese mouse model of diet-induced and biopsy-confirmed NASH

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Detailed Analyses of the Antifibrotic effects of INT-767, a dual FXR/TGR5 agonist, in an obese mouse model of diet-induced and biopsy-confirmed NASH

机译：INT-767，双FXR / TGR5激动剂，在饮食诱导和活检证实纳什的肥胖小鼠模型中的抗纤维化效应的详细分析

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来源
《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2017年第1期|共1页
作者
Veidal Sanne Skovgaard; Feigh Michael; Hansen Henrik B.; Jelsing Jacob; Vrang Niels; Petitjean Matthieu; Chen Li; Young Mark; Roth Jonathan D.;
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作者单位

Gubra Horsholm Denmark;

Gubra Horsholm Denmark;

Gubra Horsholm Denmark;

Gubra Horsholm Denmark;

Gubra Horsholm Denmark;

Intercept Pharmaceut San Diego CA USA;

Genesis Imaging Serv Princeton NJ USA;

Intercept Pharmaceut San Diego CA USA;

Intercept Pharmaceut San Diego CA USA;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Detailed Analyses of the Antifibrotic effects of INT-767, a dual FXR/TGR5 agonist, in an obese mouse model of diet-induced and biopsy-confirmed NASH [J] . Veidal Sanne Skovgaard, Feigh Michael, Hansen Henrik B., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：INT-767，双FXR / TGR5激动剂，在饮食诱导和活检证实纳什的肥胖小鼠模型中的抗纤维化效应的详细分析
2. The FXR/TGR5 dual agonist INT-767 prevents and reverses Western diet-induced NASH and modulates major lipid metabolic pathways in mice [J] . Wang Xiaoxin, Libby Andrew, Ranjit Suman, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：FXR / TGR5双激动剂INT-767可防止并逆转西方饮食诱导的肿瘤，调节小鼠中的主要脂质代谢途径
3. HP-01-006 The dual FXR/TGR5 agonist INT-767 counteracts nonalcoholic steatohepatitis and erectile dysfunction in a rabbit model of high fat diet-induced metabolic syndrome [J] . L. Vignozzi, I. Cellai, S. Filippi, The journal of sexual medicine . 2017,第4期

机译：HP-01-006双重FXR / TGR5激动剂INT-767抵消了高脂肪饮食诱导的代谢综合征的兔模型中的非酒精性脱皮炎和勃起功能障碍
4. Fat-water MRI is sensitive to local adipose tissue inflammatory changes in a diet-induced obesity mouse model at 15T [C] . Henry H. Ong, Corey D. Webb, Marnie L. Gruen, Conference on biomedical applications in molecular, structural, and functional imaging . 2015

机译：在15T饮食诱导的肥胖小鼠模型中，脂肪水MRI对局部脂肪组织的炎症变化敏感
5. Effects of adipogenesis on insulin sensitivity: Two time-course studies in diet-induced obese mouse models [D] . Loe, Yu-chi Cynthia 2008

机译：脂肪形成对胰岛素敏感性的影响：饮食诱导的肥胖小鼠模型中的两个时程研究
6. Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH [O] . Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Christina Christoffersen, 2019

机译：饮食诱导的活检证实的NASH肥胖小鼠模型中基于活检的药物作用的有效性
7. The dual FXR/TGR5 agonist INT-767 reduces visceral fat mass, promoting preadipocyte brown differentiation, mitochondrial function and insulin sensitivity in a rabbit model of high fat diet-induced metabolic syndrome [O] . Linda Vignozzi, Ilaria Cellai, Sandra Filippi, 2016

机译：双重FXR / TGR5激动剂INT-767可降低内脏脂肪块，促进高脂饮食诱导代谢综合征的兔模型中的前脂肪细胞棕色分化，线粒体功能和胰岛素敏感性

Detailed Analyses of the Antifibrotic effects of INT-767, a dual FXR/TGR5 agonist, in an obese mouse model of diet-induced and biopsy-confirmed NASH

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