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首页> 外文期刊>Vaccine >Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes
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Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes

机译：流感病毒样颗粒可以容纳多种血凝素亚型，并保护多种流感类型和亚型

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Despite existing vaccines and specific therapies, epidemics of seasonal influenza annually claim 200,000-500,000 lives worldwide. Pandemic influenza represents an even greater threat, with numerous potentially pandemic viruses circulating in nature. Development of multi-specific vaccines against multiple pandemic or seasonal strains is important for human health and the global economy. Here we report a novel virus-like particle (VLP) platform that contains three hemagglutinin (HA) subtypes. This recombinant vaccine design resulted in the expression of three HA subtypes co-localized within a VLP. Experimental triple-HA VLPs containing HA proteins derived from H5N1, H7N2, and H2N3 viruses were immunogenic and protected ferrets from challenge from all three potentially pandemic viruses. Similarly, VLPs containing HA subtypes derived from seasonal H1N1, H3N2, and type B influenza viruses protected ferrets from three seasonal influenza viruses. We conclude that this technology may represent a novel strategy for rapid development of trivalent seasonal and pandemic vaccines
机译：尽管存在现有的疫苗和特定疗法，但季节性流感的流行病每年举行全球季节性流感。大流行性流感代表了甚至更大的威胁，众多潜在的大流行病毒在自然界中循环。对多流行或季节性菌株进行多种特异性疫苗的发展对于人类健康和全球经济都很重要。在这里，我们报告了一种类似的病毒样粒子（VLP）平台，其含有三种血凝素（HA）亚型。该重组疫苗设计导致三种HA亚型在VLP内局部化的表达。含有源自H5N1，H7N2和H2N3病毒的HA蛋白的实验性三丙位VLP是免疫原性的，受到来自所有三种潜在的大流行病毒的攻击的免疫原性和受保护的雪貂。类似地，含有衍生自季节性H1N1，H3N2和B型流感病毒的HA亚型的VLP，受到三种季节性流感病毒的保护雪貂。我们得出结论，这项技术可能代表三价季节性和大流行疫苗的快速发展的新战略

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