Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice

首页> 外文期刊>Vaccine >Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice

【24h】

Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice

机译：对小鼠亚基疫苗候选的蛋白病毒前和融合后融合后和后融合后的融合后和融合后的乳腺疫苗

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Human metapneumovirus (hMPV) is an important respiratory pathogen especially in young children and elderly subjects. Our objective was to assess the immunogenicity and protection conferred by predominant pre- and post-fusion (F) hMPV-F constructs in Balb/C mice. Immunizations without adjuvant were not immunogenic whereas alum-adjuvanted hMPV-F proteins, regardless of their conformations, generated comparable neutralizing antibody titers with undetectable pulmonary viral titers following viral challenge. In conclusion, we found no apparent advantage for mixtures of predominant pre-fusion F proteins over post-fusion conformations for hMPV vaccination in opposite to recent data obtained with the human respiratory syncytial virus. (C) 2020 Elsevier Ltd. All rights reserved.

机译：人孢子虫（HMPV）是一个重要的呼吸道理原，特别是在幼儿和老年人受试者中。我们的目的是评估Palb / C小鼠的主要和融合后（F）HMPV-F构建体赋予的免疫原性和保护。没有佐剂的免疫不是免疫原性，而无论它们的构象，无论均匀，均无明矾 - 辅助的HMPv-F蛋白质，在病毒攻击后产生了与未检测到的肺病毒滴度的相当中和抗体滴度。总之，我们发现在与人类呼吸合胞病毒的最近获得的近期数据相反的HMPV疫苗接种的融合后构象上的主要预融合蛋白的混合物没有明显的优势。（c）2020 elestvier有限公司保留所有权利。

著录项

来源
《Vaccine》 |2020年第9期|共6页
作者

展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Balb/C; hMPV; Fusion protein; Pre-fusion; Vaccine; Immunisation;

机译：BALB / C;HMPV;融合蛋白;预融合;疫苗;免疫;

相似文献

外文文献
中文文献
专利

1. Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice [J] . Vaccine . 2020,第9期

机译：对小鼠亚基疫苗候选的蛋白病毒前和融合后融合后和后融合后的融合后和融合后的乳腺疫苗
2. Evaluation in Mice of the Immunogenicity of a Tetravalent Subunit Vaccine Candidate Against Dengue Virus Using Mucosal and Parenteral Immunization Routes [J] . Lazo Vazquez Laura, Gil Gonzalez Lazaro, Marcos Lopez Ernesto, Viral immunology . 2017,第5期

机译：使用粘膜和肠胃外免疫途径对Dengue病毒免疫原性小鼠的评价
3. Evaluation in mice of the immunogenicity and protective efficacy of a tetravalent subunit vaccine candidate against dengue virus [J] . Lazo Laura, Izquierdo Alienys, Suzarte Edith, Microbiology and Immunology . 2014,第4期

机译：在小鼠中评估四价亚基疫苗候选物对登革热病毒的免疫原性和保护功效
4. DEVELOPMENT OF A VACCINE BASED ON RECOMBINANT SUBUNIT PROTEINS TO PROTECT HUMANS AND ANIMALS AGAINST FILOVIRUS DISEASE [C] . Axel T. Lehrer, Michael M. Lieberman Vaccine technology VI . 2016

机译：基于重组亚单位蛋白的疫苗的开发以保护人类和动物抵抗黄萎病
5. The evaluation of type III secretion apparatus components as subunit vaccine candidates against Shigella and Salmonella infection in mice. [D] . Perryman, Rian Mae. 2011

机译：评估III型分泌设备成分作为候选抗亚克力和沙门氏菌感染的亚单位疫苗的小鼠。
6. Infection of Nonhuman Primates with Recombinant Human Metapneumovirus Lacking the SH G or M2-2 Protein Categorizes Each as a Nonessential Accessory Protein and Identifies Vaccine Candidates [O] . Stéphane Biacchesi, Quynh N. Pham, Mario H. Skiadopoulos, 2005

机译：缺乏SHG或M2-2蛋白的重组人间质肺炎病毒感染非人灵长类动物可将其归类为非必需的辅助蛋白并鉴定出疫苗候选者。
7. Infection of Nonhuman Primates with Recombinant Human Metapneumovirus Lacking the SH, G, or M2-2 Protein Categorizes Each as a Nonessential Accessory Protein and Identifies Vaccine Candidates [O] . Biacchesi, Stéphane, Pham, Quynh N., Skiadopoulos, Mario H., 2005

机译：缺乏SH，G或M2-2蛋白的重组人间质肺炎病毒感染非人灵长类动物可将其归类为非必需的辅助蛋白并鉴定出疫苗候选者。

Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice

摘要

著录项

相似文献

相关主题

期刊订阅