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Duration of immunity in recipients of two doses of 17DD yellow fever vaccine

机译：两剂17dd黄热病疫苗接受者免疫持续时间

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Antibody levels following yellow fever vaccination (YFV) decrease considerably with time, leaving a substantial proportion of single-dose recipients seronegative after 10 years. Little is known about the persistence of immunity after two or more dosesof the vaccine. This study was designed to verify the current immune status of adults who had received two or more doses of YFV.A cross-sectional study assessed the immune status for yellow fever according to time since the latest YFV: second dose at 30-45 days (reference group), 1 -5 years, 6-9 years and 10 years or more; and three or more doses. Volunteers had their vaccination cards checked and were interviewed before having a blood sample drawn for titration of neutralizing YF antibodies, and beingtested for dengue IgG. The proportion seropositive (titer > 1:50) and the geometric mean titers (GMT) were compared among the subgroups of time since the latest YFV.Participants (n = 323) were predominantly female (80.5%) and had a median age of 34 years (range 18-76). In the reference group (n = 99), 69% were seropositive before the second dose. After revaccination, the proportions seropositive (95% C.I.) were 100% (96-100%) in the reference subgroup, 90% (83-95%) in the 1-5 year subgroup (n = 109), 86% (77-92%) in the 6-9 year subgroup (n = 92) and 86% (57-98%) in the 10+years subgroup (n = 14). Only 9 participants with more than 2 previous doses of YFV were eligible for the study, and 8 of them were seropositive. Sociodemographic variables, age atvaccination and previous dengue infection did not confound the association of seropositivity to time since the last YFV.The results support the need of booster doses of the YFV to maintain antibody levels consistent with protection, and indicate that a small proportion of individuals may need more than two doses, provided that priority is given to primovaccination of all susceptibles.
机译：黄热病疫苗接种后的抗体水平随着时间的推移而显着降低，在10年后留下大量比例的单剂量受试者。关于疫苗两种或多种剂量后免疫的持续性毫无疑问。本研究旨在验证收到两种或多种剂量YFV.A横截面研究的成年人的当前免疫状态，根据最新的YFV评估了黄热病的免疫状态：30-45天的第二剂（参考组），1-5岁，6-9岁及10年或更长时间;和三个或更多剂量。志愿者在捕获的疫苗接种卡上进行了接受采访，然后进行了血液样品，用于滴定中和Yf抗体，并为登革热IgG捕获。比较血清阳性（滴度> 1:50）和几何平均滴度（GMT）在最新的YFV.Participants（n = 323）以来的时间亚组中，主要是女性（80.5％），中位年龄为34岁年（范围18-76）。在参考组（n = 99）中，在第二剂量之前69％是血清阳性。在RevactActination后，参考亚组的比例血清阳性（95％CI）为100％（96-100％），90％（83-95％）在1-5年亚组（n = 109），86％（77 -92％）在6-9年亚组（n = 92）和10 +年子组（n = 14）中的86％（57-98％）。只有9名以上剂量的YFV的9名参与者有资格参加研究，其中8名是血清阳性。社会渗目变量，年龄AtvAccation和以前的登革热感染没有混淆自上次YFV以来血清系阳性与时间的关联。结果支持增强剂量的YFV的需要，以维持与保护一致的抗体水平，并表明个体的一小部分可能需要超过两剂，只要优先考虑所有易感性的Primovaccation。

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