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首页> 外文期刊>Vaccine >Protective efficacy in farmed ducks of a duck enteritis virus-vectored vaccine against H5N1, H5N6, and H5N8 avian influenza viruses
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Protective efficacy in farmed ducks of a duck enteritis virus-vectored vaccine against H5N1, H5N6, and H5N8 avian influenza viruses

机译：鸭肠炎病毒疫苗的养殖疗效对H5N1，H5N6和H5N8禽流感病毒的保护疗效

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摘要

Ducks play a key role in the maintenance and spread of avian influenza viruses (AIVs) in nature, and control of AIVs in ducks has important implications for AIV eradication from poultry. We previously constructed a recombinant duck enteritis virus (DEV), rDEVus78HA, that expresses the HA gene of an H5N1 AIV and showed that rDEVus78HA immunization provides complete protection against both DEV and H5N1 AIV challenge in specific-pathogen-free ducks. In this study, we performed a 60-week clinical trial and found that this rDEVus78HA vaccine can function as a bivalent vaccine in farmed ducks against lethal challenge with DEV and H5N1 virus. Moreover, we found that rDEVus78HA-vaccinated ducks were efficiently protected against challenges with recently isolated heterologous H5N6 and H5N8 viruses. Our results demonstrate that rDEVus78HA could be extremely valuable for the control of DEV and H5 AlVs in ducks. (C) 2019 Elsevier Ltd. All rights reserved.
机译：鸭子在自然界中的维护和传播中发挥着关键作用，并且对鸭子的AIV的控制对来自家禽的AIV根除具有重要意义。 我们以前构建了重组鸭炎病毒（DEV），Rdevus78HA，其表达H5N1 AIV的HA基因，并显示RDEVUS78HA免疫提供了针对特定病原体无菌鸭的DEV和H5N1 AIV挑战的完全保护。 在这项研究中，我们进行了60周的临床试验，发现该Rdevus78HA疫苗可以用作养殖鸭子的二价疫苗免受致命攻击与Dev和H5N1病毒。 此外，我们发现Rdevus78HA接种疫苗的鸭子有效地保护避免最近分离的异源H5N6和H5N8病毒的攻击。 我们的结果表明，Rdevus78HA对鸭子的DEV和H5 ALVS来说非常有价值。 （c）2019 Elsevier Ltd.保留所有权利。

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  • 来源
    《Vaccine》 |2019年第40期|共5页
  • 作者

    Chen Pucheng; Ding Leilei; Jiang Yongping; Zeng Xianying; Deng Guohua; Shi Jianzhong; Li Yanbing; Liu Liling; Zhao Yuhui; Hu Yuzhen; Liu Jinxiong; Chen Hualan;

  • 作者单位

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

    Chinese Acad Agr Sci State Key Lab Vet Biotechnol Harbin Vet Res Inst Harbin 150069 Heilongjiang Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Duck enteritis virus-vectored vaccine; H5 avian influenza viruses; Farmed ducks; Clinical trial;

    机译：鸭肠炎病毒矢量疫苗;H5禽流感病毒;养殖鸭;临床试验;

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