Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial

Wildes Tyler J.; Grippin Adam; Fasanya Henrietta; Dyson Kyle A.; Brantly Mark

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Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial

机译：阿托伐他汀对健康志愿者23价肺炎球菌多糖疫苗接种的体液免疫反应的影响：Statvax随机临床试验

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Background: The immunomodulatory effects of statins on vaccine response remain uncertain. Therefore, the objective of this study was to determine if atorvastatin enhances pneumococcal-specific antibody titer following 23-valent pneumococcal polysaccharide vaccination.

机译：背景：他汀类药物对疫苗反应的免疫调节作用仍然不确定。因此，本研究的目的是确定阿托伐他汀是否增强了23例肺炎球菌多糖疫苗接种后的肺炎球菌特异性抗体滴度。

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《Vaccine》 |2019年第10期|共12页
作者
Wildes Tyler J.; Grippin Adam; Fasanya Henrietta; Dyson Kyle A.; Brantly Mark;
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作者单位

Univ Florida Coll Med MD PhD Program Gainesville FL 32610 USA;

Univ Florida Coll Med MD PhD Program Gainesville FL 32610 USA;

Univ Florida Coll Med MD PhD Program Gainesville FL 32610 USA;

Univ Florida Coll Med MD PhD Program Gainesville FL 32610 USA;

Univ Florida Coll Med MD PhD Program Gainesville FL 32610 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Pneumococcal pneumonia; Atorvastatin; Vaccination; Healthy volunteers; Humoral immunity;

机译：肺炎球菌肺炎;阿托伐他汀;疫苗接种;健康志愿者;体液免疫;

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1. Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial [J] . Wildes Tyler J., Grippin Adam, Fasanya Henrietta, Vaccine . 2019,第10期

机译：阿托伐他汀对健康志愿者23价肺炎球菌多糖疫苗接种的体液免疫反应的影响：Statvax随机临床试验
2. Safety and immunogenicity of 23-valent pneumococcal polysaccharide vaccine in 2 to 70 year old healthy people in China: A phase III double blind, randomized clinical trial [J] . Li Guifan, Liang Qi, Shi Jichun, Human vaccines & immunotherapeutics. . 2015,第3期

机译：23价肺炎球菌多糖疫苗在中国2至70岁健康人群中的安全性和免疫原性：III期双盲，随机临床试验
3. Adjuvant system AS02(V) enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials [J] . Leroux-Roels Isabel, Devaster Jeanne-Marie, Leroux-Roels Geert, Vaccine . 2015,第4期

机译：佐剂系统AS02（V）在健康的年轻人和老年人中增强对肺炎球菌蛋白PhtD疫苗的体液和细胞免疫反应：随机对照试验
4. THE IMMUNE RESPONSE IN DOGS WITH MELANOMA TO DISIALOGANGLIOSIDE GD3 VACCINATION: A PHASE 1 CLINICAL TRIAL [C] . Rowan Milner, Jim Farese, Marc Salute, Annual Conference of the Veterinary Cancer Society . 2009

机译：黑色素瘤的免疫应答与脱毛阳岩GD3疫苗接种：1期临床试验
5. Immune responses of pneumococcal polysaccharide and conjugate vaccines in adults: Effect of human immunodeficiency virus infection [D] . Ahmed, Faruque 1995

机译：成人肺炎球菌多糖和结合疫苗的免疫应答：人类免疫缺陷病毒感染的影响
6. Conjugate and 23-valent pneumococcal polysaccharide booster vaccination in asplenic patients with thalassemia major: A randomized clinical trial study [O] . Mohammad Sadegh Rezai, Javad Ghaffari, Mohammadreza Mahdavi, 2017

机译：重型地中海贫血患者的结合和23价肺炎球菌多糖加强免疫接种：一项随机临床试验研究
7. Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: randomised, controlled trials [O] . Leroux-Roels, Isabel, Devaster, Jeanne-Marie, Leroux-Roels, Geert, 2015

机译：辅助系统as02V增强健康年轻人和老年人肺炎球菌蛋白phtD疫苗的体液和细胞免疫应答：随机对照试验

Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial

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