Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4(high) memory cell proliferation in activated whole blood cultures

Haredy Ahmad M.; Takei Michihiro; Iwamoto Shin-ichi; Ohno Masafumi; Kosaka Mitsuyo; Hirota Kazue; Koketsu Ritsuko; Okuno Toshiomi; Ikuta Kazuyoshi; Yamanishi Koichi; Ebina Hirotaka

首页> 外文期刊>Vaccine >Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4(high) memory cell proliferation in activated whole blood cultures

【24h】

Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4(high) memory cell proliferation in activated whole blood cultures

机译：通过评估活化的全血培养中的响应CD4（高）记忆细胞增殖，通过评估响应CD4（高）记忆细胞增殖来定量对毒液菌带群病毒的细胞介导的免疫应答

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background: Herpes zoster (HZ) is caused by reactivation of a latent varicella zoster virus (VZV). The potential to develop HZ increases with age due to waning of memory cell-mediated immunity (CMI), mainly the CD4 response. Therefore, VZV-CD4-memory T cells (CD4-M) count in blood could serve as a barometer for HZ protection. However, direct quantification of these cells is known to be difficult because they are few in number in the blood. We thus developed a method to measure the proliferation level of CD4-M cells responding to VZV antigen in whole blood culture.

机译：背景：疱疹（Hz）是由潜在的毒液疱疹病毒（VZV）的再活化引起的。由于记忆细胞介导的免疫（CMI）的衰退，由于CD4反应的衰退，由于衰退，因此随着年龄增加的潜力随着年龄而增加。因此，血液中的VZV-CD4-Memory T细胞（CD4-M）计数可以用作Hz保护的晴雨表。然而，已知将这些细胞的直接定量困难，因为它们在血液中的数量很少。因此，我们开发了一种测量全血液培养物响应VZV抗原的CD4-M细胞增殖水平的方法。

著录项

来源
《Vaccine》 |2019年第36期|共8页
作者
Haredy Ahmad M.; Takei Michihiro; Iwamoto Shin-ichi; Ohno Masafumi; Kosaka Mitsuyo; Hirota Kazue; Koketsu Ritsuko; Okuno Toshiomi; Ikuta Kazuyoshi; Yamanishi Koichi; Ebina Hirotaka;
展开▼
作者单位

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

Takei Clin Osaka Japan;

Iwamoto Med Clin Osaka Japan;

Ohno Clin Osaka Japan;

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

Hyogo Coll Med Dept Microbiol Nishinomiya Hyogo Japan;

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ BIKEN Res Fdn Microbial Dis Biken Ctr Innovat Vaccine Res &

Dev 3-1 Yamada Oka Suita Osaka 5650871 Japan;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
VZV-specific CD4 memory T cells; Herpes zoster immune response; VZV cell mediated immunity; Memory response; Whole blood assay; CD4(high);

机译：VZV特异性CD4记忆T细胞;疱疹免疫应答;VZV细胞介导的免疫;记忆响应;全血测定;CD4（高）;

相似文献

外文文献
专利

1. Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4(high) memory cell proliferation in activated whole blood cultures [J] . Haredy Ahmad M., Takei Michihiro, Iwamoto Shin-ichi, Vaccine . 2019,第36期

机译：通过评估活化的全血培养中的响应CD4（高）记忆细胞增殖，通过评估响应CD4（高）记忆细胞增殖来定量对毒液菌带群病毒的细胞介导的免疫应答
2. Comparison of a glycoprotein E-based ELISA with a varicella-zoster whole-virus ELISA for the quantification of varicella vaccine immune responses in young children [J] . Vaccine . 2020,第17期

机译：将糖蛋白E基ELISA与幼稚蛋白酶的蛋白酶酶的比较进行幼儿毒液疫苗免疫应答的量化
3. Varicella-Zoster Virus-Specific, Cell-Mediated Immunity With Interferon-Gamma Release Assay After Vaccination of College Students With no or Intermediate IgG Antibody Response [J] . Terada Kihei, Itoh Yuri, Fujii Akihide, Journal of Medical Virology . 2015,第2期

机译：水痘带状疱疹病毒特异性细胞介导的免疫，无或中度IgG抗体应答的大学生疫苗接种后，干扰素-γ释放测定
4. Antiviral Activity of Cisplatin Derivatives of Methotrexate Against Vaccinia Virus, Varicella Zoster Virus (VZV), Reovirus ST3, and Herpes Simplex Virus (HSV-1) [C] . Michael R. Roner, Charles E. Carraher Jr., Salima Dhanji PMSE Symposia . 2005

机译：甲氨蝶呤对痘苗病毒，植物疱疹病毒（VZV），reoVirus ST3和单纯疱疹病毒（HSV-1）的抗病毒活性
5. Setting the Stage for a Potential Varicella-Zoster Virus (VZV)-Based HIV Vaccine: Characterization of the Mucosal Immune Response Induced by VZV Vaccination in Humans [D] . Perciani, Catia Taniela. 2019

机译：为潜在的水痘 - 带状疱疹病毒（VZV）的阶段为基础的HIV疫苗：在人类中vzV疫苗接种诱导的粘膜免疫应答的表征
6. Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation [O] . Insaf Salem Fourati, Anne-Julie Grenier, Élyse Jolette, 2014

机译：脐带血移植后评估水痘-带状疱疹病毒特异性细胞介导的免疫力的IFN-γELISpot检测方法的开发
7. Comparison of two methods for detecting varicella-zoster virus antibody with varicella-zoster virus cell-mediated immunity [O] . A Weinberg, A R Hayward, H B Masters, 1996

机译：检测水痘 - 带状疱疹病毒细胞介导免疫检测水痘 - 带状疱疹病毒抗体的两种方法的比较

Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4(high) memory cell proliferation in activated whole blood cultures

摘要

著录项

相似文献

相关主题

期刊订阅