Vaccines against respiratory syncytial virus: The time has finally come

Graham Barney S.

首页> 外文期刊>Vaccine >Vaccines against respiratory syncytial virus: The time has finally come

【24h】

Vaccines against respiratory syncytial virus: The time has finally come

机译：针对呼吸道合胞病毒的疫苗：时间终于来了

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Respiratory syncytial virus causes a significant public health burden, particularly in very young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a whole formalin-inactivated RSV vaccine, and the complex biology of the virus and the neonate have delayed the development of effective vaccines. However, new insights into factors associated with ERD and breakthroughs in understanding the antigenic structure of the fusion (F) glycoprotein have increased optimism that vaccine development is possible. This has led to investment of time and resources by industry, regulatory authorities, governments, and nonprofit organizations to develop the infrastructure needed to make the advanced clinical development of RSV vaccine candidates a reality. Published by Elsevier Ltd.

机译：呼吸道合胞病毒导致大量的公共卫生负担，特别是在非常年轻的婴儿和虚弱的老年人。增强RSV疾病（ERD）的遗产来自整个福尔马林灭活的RSV疫苗，以及病毒和新生儿的复杂生物学延迟了有效疫苗的发展。然而，在理解融合（F）糖蛋白的抗原结构具有ERD和突破性相关的因素的新见解增加了疫苗发育的乐观态度增加。这导致了行业，监管机构，政府和非营利组织的时间和资源投资，以制定所需的基础设施，以使RSV疫苗候选人的先进临床发展成为现实。 elsevier有限公司出版

著录项

来源
《Vaccine》 |2016年第30期|共7页
作者
Graham Barney S.;
展开▼
作者单位

NIAID Vaccine Res Ctr NIH 9000 Rockville Pike Bethesda MD 20892 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
RSV; Immunization; Vaccination; Structure-based vaccine design; Fusion; Neutralization; Vaccine-enhanced illness; Bronchiolitis; Pneumonia; Infants; Elderly; Th2; Eosinophilia; Subunit vaccine; Vaccine vector; Wheezing; Asthma; Protein conformation; Epitope;

机译：rsv;免疫;疫苗接种;基于结构的疫苗设计;融合;中和;疫苗增强的疾病;肺炎;肺炎;婴儿;嗜血杆菌;嗜酸性疫苗;嗜酸性疫苗;疫苗v v v v疫苗;喘息;哮喘;哮喘;表位;表位;

相似文献

外文文献
中文文献
专利

1. Vaccines against respiratory syncytial virus: The time has finally come [J] . Graham Barney S. Vaccine . 2016,第30期

机译：针对呼吸道合胞病毒的疫苗：时间终于来了
2. The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines [J] . Wright PF, Karron RA, Belshe RB, Vaccine . 2007,第42期

机译：接种减毒活呼吸道合胞病毒疫苗后，没有出现野生型呼吸道合胞病毒感染导致疾病增强的情况
3. Contribution of respiratory syncytial virus G antigenicity to vaccine-enhanced illness and the implications for severe disease during primary respiratory syncytial virus infection. [J] . Johnson TR, Graham BS The Pediatric infectious disease journal . 2004,第1Suppla期

机译：呼吸道合胞病毒G抗原性对疫苗增强疾病的影响以及在原发性呼吸道合胞病毒感染期间对严重疾病的影响。
4. A meta-analysis of vaccine effectiveness against bovine herpesvirus, bovine viral diarrhea virus, bovine respiratory syncytial virus, and parainfluenza-type 3 virus in cattle for bovine respiratory di [C] . M.E. Theurer, R.L. Larson, B.J. White Annual Conference of the American^Association^of^Bovine^Practitioners., Conference . 2014

机译：对牛疱疹病毒，牛病毒性腹泻病毒，牛呼吸道和血酸病毒和牛牛呼吸道牛牛牛呼吸道型病毒和Parainfluenza型3病毒的疫苗效果的荟萃分析
5. Respiratory Syncytial Virus Vaccine Design Using Structure Based Machine Learning Models [D] . McCarty, Thomas C. 2021

机译：使用基于结构的机器学习模型设计呼吸道合胞病毒疫苗设计
6. Vaccines Against Respiratory Syncytial Virus: The Time Has Finally Come [O] . Barney S. Graham -1

机译：预防呼吸道合胞病毒的疫苗：时机终于来临
7. The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines [O] . Peter F. Wright, Ruth A. Karron, Robert B. Belshe, 2007

机译：收到活型，减毒，呼吸道合胞病毒疫苗后发生野生型呼吸道合胞病毒感染的增强疾病
8. Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines. [R] . forsyth,ben r. phillips,charles a. 1971

机译：呼吸道合胞病毒的实验室和抗原研究;呼吸道合胞体，脑膜炎球菌和肺炎球菌多糖疫苗的评估。

Vaccines against respiratory syncytial virus: The time has finally come

摘要

著录项

相似文献

相关主题

期刊订阅