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Efficacy of an inactivated Mycoplasma hyorhinis vaccine in pigs

机译：猪灭活的支原体症症症症的疗效

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Lameness and polyserositis in pigs caused by Mycoplasma hyorhinis are generally treated with antibiotics and may require multiple doses. The costs of these antibiotics combined with economic losses from culling and reduced feed conversion due to lameness are hardships to the swine producer. In this study we have demonstrated efficacy of an inactivated M. hyorhinis vaccine administered to three-week old caesarian-derived colostrum-deprived piglets. Three doses of vaccine (high, medium, and low) were evaluated and compared to a placebo control. Mycoplasma hyorhinis challenge occurred three weeks after vaccination. Pigs were observed for lameness and respiratory distress for three weeks following challenge. Pigs were then euthanized and a gross pathological evaluation for polyserositis and arthritis was performed. A minimum immunizing dose of vaccine was defined as containing at least 7.41 x 10(7) CCU of M. hyorhinis per 2.0 mL dose as represented by the medium dose vaccine. This vaccine provided significant reductions in lameness and pericarditis with preventive fractions of 0.76 (95% CI [0.26, 0.92]) and 0.58 (95% CI [0.31, 0.74]), respectively, compared to the placebo control group. A significant increase in post-challenge weight gain (P .0001) was also achieved with this vaccine, with an average daily gain (ADG) of 0.92 lbs/day compared to 0.57 lbs/day in the placebo group. (C) 2017 The Authors. Published by Elsevier Ltd.
机译：由支原体症症症引起的猪的跛足和多晶硅通常用抗生素治疗，可能需要多剂量。这些抗生素的成本与来自胶质性的剔除和减少的饲料转换相结合的成本与猪生产者困难。在这项研究中，我们已经证明了给予三周大的剖腹产初乳剥皮仔猪的灭活M. hyorhinis疫苗的疗效。评估三剂疫苗（高，培养基和低），并与安慰剂对照进行比较。疫苗接种后，支原体症症症症攻击发生了三周。在挑战后三周观察到跛足和呼吸窘迫的猪。然后对猪进行了安乐死，进行了对多电肌和关节炎的总病理评估。将最小免疫剂量的疫苗定义为含有2.0ml剂量的至少7.41×10（7）CCU的M. hyorhinis，如培养基剂量疫苗所示。与安慰剂对照组相比，该疫苗可在跛足和心膜膜炎中提供跛行和心膜膜炎的显着降低，其预防级分别为0.76（95％CI [0.26,0.92]）和0.58（95％CI [0.31,0.74]）。在该疫苗中还达到了攻击后重量增益（P＆LT; .0001）的显着增加，其平均每日增益（ADG）为0.92磅/天，而安慰剂组中的0.57磅/天。 （c）2017年作者。 elsevier有限公司出版

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