Reduced nontypeable Haemophilus influenzae lower airway infection in children with chronic endobronchial suppuration vaccinated with the 10-valent pneumococcal H. influenzae protein D conjugate vaccine

Hare Kim M.; Smith-Vaughan Heidi C.; Leach Amanda J.; Pizzutto Susan J.; McCallum Gabrielle B.; Chang Anne B.

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Reduced nontypeable Haemophilus influenzae lower airway infection in children with chronic endobronchial suppuration vaccinated with the 10-valent pneumococcal H. influenzae protein D conjugate vaccine

机译：用10价肺炎球菌H.Compenenzae蛋白D缀合物疫苗疫苗疫苗的慢性肺结气疫苗疫苗的儿童中的不可缺乏血液血液嗜血杆菌感染

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Background: Nontypeable Haemophilus influenzae (NTHi), the most common bacterial lower airway infection in children with protracted bacterial bronchitis, is associated with progression to bronchiectasis. We determined whether vaccination with 10-valent pneumococcal NTHi protein-D conjugate vaccine (PHiD-CV) reduced NTHi lower airway infection compared to children not PHiD-CV-vaccinated. Our unique childhood vaccination schedule and prospective 9-year bronchoalveolar lavage (BAL) collection provided an exclusive opportunity to examine this hypothesis.

机译：背景：嗜血杆菌（Nthi），持久性细菌支气管炎儿童中最常见的细菌较低的气道感染，与支气管扩张有关。与儿童没有疫苗接种疫苗，我们确定了与10价肺炎球菌NTHI蛋白-D蛋白-D蛋白-D蛋白-D蛋白-D疫苗疫苗（PhID-CV）的疫苗接种疫苗是否减少了NTHI下气道感染。我们独特的儿童疫苗接种时间表和潜在9年的支气管肺泡灌洗（BAL）集合提供了检查这一假设的独家机会。

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来源
《Vaccine》 |2018年第13期|共7页
作者
Hare Kim M.; Smith-Vaughan Heidi C.; Leach Amanda J.; Pizzutto Susan J.; McCallum Gabrielle B.; Chang Anne B.;
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作者单位

Menzies Sch Hlth Res Child Hlth Div POB 41096 Casuarina NT 0811 Australia;

Menzies Sch Hlth Res Child Hlth Div POB 41096 Casuarina NT 0811 Australia;

Menzies Sch Hlth Res Child Hlth Div POB 41096 Casuarina NT 0811 Australia;

Menzies Sch Hlth Res Child Hlth Div POB 41096 Casuarina NT 0811 Australia;

Menzies Sch Hlth Res Child Hlth Div POB 41096 Casuarina NT 0811 Australia;

Menzies Sch Hlth Res Child Hlth Div POB 41096 Casuarina NT 0811 Australia;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Nontypeable Haemophilus influenzae; Lower airway infection; Protracted bacterial bronchitis; Chronic suppurative lung disease; Bronchiectasis; Pneumococcal conjugate vaccine;

机译：嗜血杆菌嗜血杆菌;较低的气道感染;长期细菌支气管炎;慢性化脓性肺病;支气管扩张;肺炎球菌缀合物疫苗;

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1. Reduced nontypeable Haemophilus influenzae lower airway infection in children with chronic endobronchial suppuration vaccinated with the 10-valent pneumococcal H. influenzae protein D conjugate vaccine [J] . Hare Kim M., Smith-Vaughan Heidi C., Leach Amanda J., Vaccine . 2018,第13期

机译：用10价肺炎球菌H.Compenenzae蛋白D缀合物疫苗疫苗疫苗的慢性肺结气疫苗疫苗的儿童中的不可缺乏血液血液嗜血杆菌感染
2. Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine [J] . Amanda J Leach, Christine Wigger, Kim Hare, BMC Pediatrics . 2015,第1期

机译：过渡到10价肺炎球菌不可分型流感嗜血杆菌D结合蛋白疫苗后，减少了不可分型流感嗜血杆菌对中耳的感染，但对肺炎链球菌无效
3. Use of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) in an Australian Indigenous paediatric population does not alter the prevalence of nontypeable Haemophilus influenzae without the protein D gene [J] . Vaccine . 2019,第30期

机译：在澳大利亚土着儿科人群中使用10价肺炎球菌嗜血杆菌嗜血杆菌（Phid-cv10），不会改变无蛋白D基因的无去嗜血杆菌流感的患病率
4. Analysis of dynamics of Th17 cells in chronic middle ear inflammation induced by nontypeable Haemophilus influenzae [C] . Hirano T., Kodama S., Kawano T., Extraordinary International Symposium on Recent Advances in Otitis Media . 2014

机译：嗜血杆菌诱导慢性中耳炎症Th17细胞动力学分析
5. Protein Vaccines Against Acute Otitis Media Caused by Nontypeable Haemophilus influenzae in a Murine Model [D] . Zavorin, Mark. 2018

机译：蛋白质疫苗针对鼠模型中的不可迁移血液血液嗜血杆菌引起的急性中耳炎
6. The Effect of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine on H. influenzae in Healthy Carriers and Middle Ear Infections in Iceland [O] . Hildigunnur Sveinsdóttir, Jana Birta Björnsdóttir, Helga Erlendsdóttir, 2019

机译：10价肺炎球菌不可分型流感嗜血杆菌蛋白D结合疫苗对冰岛健康携带者和中耳感染中的流感嗜血杆菌的影响
7. The Effect of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine on H. influenzae in Healthy Carriers and Middle Ear Infections in Iceland [O] . Hildigunnur Sveinsdóttir, Jana Birta Björnsdóttir, Helga Erlendsdóttir, 2019

机译：10价肺炎球菌无卵形血液血液植物嗜流感蛋白D杂交疫苗对冰岛健康载体和中耳感染H.Complenzae的影响
8. Field Trial of Meningococcus Group A and 'Haemophilus influenzae' Type B Vaccines in Infants and Children 3 Months to 5 Years of Age: Long Term Sustenance of Immunity After Various Immunization Schedules [R] . Maekelae, P. H. , Peltola, H. , Kaeyhty, H. 1980

机译：婴儿和儿童3个月至5岁的脑膜炎球菌a组和'B型流感嗜血杆菌'疫苗的实地试验：各种免疫接种后的长期免疫保持

Reduced nontypeable Haemophilus influenzae lower airway infection in children with chronic endobronchial suppuration vaccinated with the 10-valent pneumococcal H. influenzae protein D conjugate vaccine

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