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Antigenic and sequence variability of the human respiratory syncytial virus F glycoprotein compared to related viruses in a comprehensive dataset

机译：与综合数据集中的相关病毒相比，人呼吸合胞病毒F糖蛋白的抗原和序列变异性

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摘要

A comprehensive analysis of sequence variation was carried out comparing the fusion (F) protein of human respiratory syncytial viruses (hRSV) from antigenic groups A and B with the prototype sequence of the A2 strain, also belonging to antigenic group A. The limited number of full bovine RSV F sequences available were included, as well as an extensive set of F sequences from the related human metapneumovirus (hMPV). The results were analysed in the context of the recently determined three dimensional F protein structures, with antigenic sites mapped to these. Although a high degree of sequence conservation in hRSV F exists, and sequence changes did not correlate with location of antigenic sites, preferential accumulation of amino acid changes in certain antigenic sites was noted. When the analysis was extended to hMPV F, a high number of changes was noticed, in agreement with the limited degree of sequence conservation. However, some conserved regions were noted, which may account for the limited number of cross-reactive monoclonal antibodies described between hRSV F and hMPV F. These results provide information about the degree of sequence and antigenic variation currently found in the F protein of circulating viruses. They highlight the importance of establishing a baseline dataset to monitor for future changes that might evolve should preventative immunological measures be made widely available. (C) 2018 The Authors. Published by Elsevier Ltd.
机译：对抗原基团A和B的人呼吸合胞病毒（HRSV）的融合（F）蛋白与A2菌株的原型序列进行了综合分析，还属于抗原组A.有限数量包含全牛RSV F序列，以及来自相关人类孢子虫（HMPV）的广泛的F序列。在最近确定的三维F蛋白质结构的背景下分析结果，抗原位点映射到这些。尽管HRSV F的高度序列保守，但序列变化与抗原位点的位置没有相关，注意到，注意到某些抗原位点的氨基酸变化的优先积累。当分析扩展到HMPV F时，注意到齐全的变化，同时遵守有限程度的序列保护。然而，注意到一些保守的区域，其可能考虑HRSV F和HMPV F之间描述的有限数量的交叉反应性单克隆抗体。这些结果提供了关于循环病毒的F蛋白目前发现的序列和抗原变异程度的信息。它们突出了建立基线数据集的重要性，以监测可能发展的未来变化，应广泛可用的预防性免疫措施。 （c）2018年作者。 elsevier有限公司出版

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