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Cost of herpes zoster and herpes zoster-related complications among immunocompromised individuals

机译：疱疹的成本和疱疹相关的疱疹相关的个体中的相关并发症

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Herpes zoster (HZ) is a painful dermatomal rash caused by reactivation of latent varicella-zoster virus. The incidence of HZ is increased for immunocompromised (IC) individuals. The objective of this study is to assess the healthcare costs incurred by IC individuals who develop HZ with or without associated complications. We conducted a retrospective case-control study across the US over a 5-year period, based on health insurance claims data for individuals aged &= 50 years identified as IC by disease or immunosuppressive treatment. A cohort of 30,107 IC individuals who experienced HZ was matched to a cohort of 113,875 IC individuals without HZ. Average all-cause healthcare costs over 18 months were calculated and compared between IC individuals with and without HZ. In addition, the costs of HZ in IC individuals with HZ-related complications were compared to the costs of those with uncomplicated HZ. During the year following HZ onset, IC individuals with HZ had on average total unadjusted costs that were US$3879 higher than the controls. After adjusting costs, controlling for comorbidities and healthcare costs before the onset of HZ, the average annual costs for HZ cases and controls without HZ were similar. HZ-related complications led to increases in average adjusted annual costs compared to uncomplicated HZ ranging from US$612 for eye complications to US$4535 for neurologic complications. In conclusion, in IC individuals, episodes of HZ lead to substantially increased unadjusted annual healthcare costs. HZ-related complications add considerably to adjusted annual healthcare costs compared to uncomplicated HZ. (C) 2018 GlaxoSmithKline Biologicals SA. Published by Elsevier Ltd.
机译：疱疹（HZ）是由潜在的毒液蛋群 - 带状疱疹病毒再激活引起的痛苦皮疹。对于免疫抑制（IC）个体，Hz的发病率增加。本研究的目的是评估具有或不具有相关并发症的HZ的IC个体产生的医疗保健费用。我们在5年期间对美国进行了一项回顾性案例对照研究，基于年龄较老年人的个人的健康保险索赔数据; GT; = 50年通过疾病或免疫抑制治疗确定为IC。经历Hz的30,107个IC个人的队列与没有HZ的113,875个IC个体的队列匹配。计算平均全部致命的医疗费用超过18个月，并在IC个人与无Hz之间进行比较。此外，将Hz与HZ相关并发症的IC个体中的Hz成本与具有简单的Hz的成本进行了比较。在HZ发病之后，患有Hz的IC个人平均不调整的成本，高于控制3879美元。调整成本后，在Hz发作前控制合并症和医疗保健费用，Hz病例和无Hz的控制的平均年度成本是相似的。与Hz相关的并发症导致平均调整后的年度成本增加，与短暂的612美元的简单Hz，用于眼部并发症为4535美元的神经系统并发症。总之，在IC个人中，赫兹的剧集导致显着增加了未经调整的年医疗保健费用。与简单的Hz相比，HZ相关的并发症会显着增加调整年度医疗费用。 （c）2018 Glaxosmithkline Biologicals SA。 elsevier有限公司出版

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