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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles
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Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles

机译：用水溶液和金纳米颗粒在水溶液中的二锌受体分子识别二膦酸盐的药物

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摘要

Metal-based anion receptors have several important applications in sensing, separation and transport of negatively charged species. Amongst these receptors, di-zinc(II) complexes are of particular interest for the recognition of oxoanions, in particular phosphate derivatives. Herein we report the synthesis of a dizinc(s) receptor and show that it has high affinity and selectivity for bisphosphonates such as alendronate and etidronate - which are used to treat a number of skeletal disorders as well as showing interesting anticancer properties. The binding mode of the di-zinc(II) receptor with alendronate and etidronate has been unambiguously established by single crystal X-ray crystallography. In addition, by modifying the backbone of the receptor, we show that the drug-loaded receptor can be attached onto gold nanoparticles as potential drug-delivery vehicles.
机译：金属基阴离子受体具有带负电物种的感测，分离和运输的几种重要应用。 在这些受体中，二锌（II）配合物特别感兴趣地识别氧化，特别是磷酸盐衍生物。 在此，我们报告了致锌受体的合成，并表明它具有高亲和力和对二膦酸盐和乙酸乙酯的选择性 - 用于治疗许多骨骼疾病以及显示有趣的抗癌性能。 通过单晶X射线晶体学，二锌（II）受体的结合模式用醛膦酸盐和etidronate明确地建立了明确建立的。 另外，通过改变受体的骨干，我们表明药物负载受体可以作为潜在的药物输送载体附着在金纳米粒子上。

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