Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II)

Loboda D.; Rowinska-Zyrek M.

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Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II)

机译：Candida albicans Zincophore和锌转运蛋白与Zn（II）和Ni（II）相互作用

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The interaction between the Pra1 zincophore and the Zrt1 zinc(II) transporter is crucial for adequate Zn(II) acquisition in Candida albicans, the most common cause of fungal infections in humans. Pointing out the precise Zn(II) binding site on Zrt1 and describing the thermodynamics of such binding are important steps, which allow one to understand the interactions between Pra1, Zn(II) and Zrt1. Zrt1 coordinates Zn(II) via the side chains of (156)His, (161)His, (162)Cys and (168)His, and this binding is stronger than the binding of Zn(II) to Pra1, allowing efficient zinc transfer from the zincophore to the zinc transporter. Additional analysis of Pra1 and Zrt1 complexes with Ni(II), another metal ion necessary for fungal survival, shows the specificity of the studied system - Ni(II) does not interfere with the Zn(II) binding to Pra1, though it might form a comparably stable complex with Zrt1.

机译：PRA1锌和ZRT1锌（II）转运蛋白之间的相互作用对于念珠菌白醛植物（II）的充分发布至关重要，是人类真菌感染的最常见原因。指向ZrT1上的精确Zn（II）结合位点，并描述这种结合的热力学是重要步骤，其允许人们了解PRA1，Zn（II）和ZrT1之间的相互作用。 Zrt1通过侧链（156）他，（161）他，（162）Cys和（168）他的侧链坐标，并且该结合比Zn（ii）与PRA1的结合强，允许有效的锌从锌转移到锌转运蛋白。用Ni（II）的PRA1和ZrT1络合物的另外的分析，真菌存活所需的另一种金属离子，表明所研究的系统 - Ni（II）的特异性不会干扰与PRA1的Zn（II）结合，尽管它可能形成与Zrt1相对稳定的复合物。

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《Dalton transactions: An international journal of inorganic chemistry》 |2018年第8期|共9页
作者
Loboda D.; Rowinska-Zyrek M.;
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Univ Wroclaw Fac Chem F Joliot Curie 14 PL-50383 Wroclaw Poland;

Univ Wroclaw Fac Chem F Joliot Curie 14 PL-50383 Wroclaw Poland;

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正文语种 eng
中图分类化学;无机化学;
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机译：Candida albicans Zincophore和锌转运蛋白与Zn（II）和Ni（II）相互作用
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Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II)

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