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首页> 外文期刊>Current treatment options in gastroenterology >Alcoholic Hepatitis.
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Alcoholic Hepatitis.

机译：酒精性肝炎。

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摘要

Alcoholic hepatitis (AH) is a common disease associated with significant morbidity and mortality. Most often the diagnosis is suggested by a history of heavy alcohol excess in a patient with features of hepatic decompensation. In its purest form, AH is a histologic diagnosis of acute hepatic inflammation in response to alcohol. The primary objective of treatment for AH is to support long-term alcohol abstinence and to achieve adequate nutrition with lifestyle modification; goal setting and education are integral to long-term medical management. Severity at presentation (calculated by way of the Maddrey score) determines outcome. Patients with AH represent a heterogeneous group with regard to severity and pathogenesis, with various therapeutic interventions assessed in patients with severe AH. To date, corticosteroids have been studied most, and despite remaining controversial, warrant a place in the treatment of selected patients. Recent advances in unraveling the aspects of disease pathogenesis in AH have raised the possibility of targeted therapies, such as anti-tumor necrosis factor-a monoclonals and pentoxifylline. Orthotopic liver transplantation is not recommended for patients with severe acute AH, as most have an unclear long-term prognosis in the context of ongoing excess alcohol ingestion at presentation.
机译：酒精性肝炎（AH）是一种常见的疾病，与高发病率和高死亡率相关。最常见的诊断是由具有肝代偿失调特征的患者中大量酒精过量的病史提示的。 AH以最纯净的形式对酒精引起的急性肝炎进行组织学诊断。治疗AH的主要目的是支持长期戒酒并通过改变生活方式来获得足够的营养;目标设定和教育对于长期医疗管理必不可少。表现的严重程度（通过Maddrey评分计算）决定结果。 AH患者在严重程度和发病机制方面代表异质性人群，在重度AH患者中评估了各种治疗干预措施。迄今为止，对糖皮质激素的研究最多，尽管仍存在争议，但仍应在某些患者的治疗中占有一席之地。揭示AH疾病发病机理方面的最新进展提高了靶向治疗的可能性，例如抗肿瘤坏死因子-α单克隆抗体和己酮可可碱。不建议对重症急性AH患者进行原位肝移植，因为大多数人在就诊时持续过量饮酒会导致长期预后不清楚。

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