Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level

Wang Xiaomei; Ji Guoxun; Shi Cen; Juan Diwu; Chen Lanhua; Gui Daxiang; Wan Jianmei; Silver Mark A.; Wang Jianqiang; Wang Shuao

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Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level

机译：铀酰渗透酮复合物的结构和热力学稳定性和U（VI）在细胞水平下的去除效果

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Deferiprone (3-hydroxy-1,2-dimethyl-4(1H)-pyridone, DFP), which is a drug clinically used for removing heavy metals in vivo, was explored for its removal efficiency towards uranium. The reaction of uranyl nitrate hexahydrate with DFP at room temperature yielded the compound [(UO2)(H2O)(C7NO2H8)(2)]4H(2)O (1), which crystallizes from a mixed solution of methanol and water (pH = 7.0). X-ray diffraction shows that the stable complexation of uranyl occurs from the coordination of two bidentate DFP ligands perpendicular to the O?U?O unit with a fifth coordinating oxygen atom coming from one water molecule, resulting in a pentagonal bipyramidal geometry. The formation constants of uranyl and DFP complexes were measured and the species distribution diagram illustrates that UO2L2 (94.6%) is the dominant uranyl-DFP complex in 0.1 M KCl solution at physiological pH = 7.4. The results from both crystallographic and potentiometric studies imply that the metal:ligand ratio is 1:2. The effectiveness of using DFP to remove uranium was examined at the cellular level, and the results suggest that it can significantly reduce the cellular uptake and increase the cellular release of U(vi) in renal proximal tubular epithelial cells (NRK-52E).

机译：探索普通吡啶酮（3-羟基-1,2-二甲基-4（1H） - 吡啶酮，DFP），其用于去除体内重金属的药物，探讨其对铀的去除效率。在室温下用DFP的铀酰六水合物的反应产生了化合物[（UO 2）（H 2 O）（C7 NO 2 H 8）（2））4H（2）O（1），其从甲醇和水的混合溶液中结晶（pH = 7.0）。 X射线衍射表明，铀酰的稳定络合发生从垂直于O 2的两只二齿DFP配体的配位，其中来自来自一个水分子的第五协调氧原子，导致五边形的双滤网几何形状。测量铀基和DFP复合物的形成常数，并且物种分布图说明了UO2L2（94.6％）是在生理pH = 7.4的0.1M KCl溶液中的主要铀酰-DFP复合物。晶体和电位研究的结果意味着金属：配体比为1：2。在细胞水平检查使用DFP去除铀的有效性，结果表明它可以显着降低肾近管上皮细胞（NRK-52e）中U（VI）的细胞释放。

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来源
《Dalton transactions: An international journal of inorganic chemistry》 |2018年第26期|共7页
作者
Wang Xiaomei; Ji Guoxun; Shi Cen; Juan Diwu; Chen Lanhua; Gui Daxiang; Wan Jianmei; Silver Mark A.; Wang Jianqiang; Wang Shuao;
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Chinese Acad Sci Shanghai Inst Appl Phys Key Lab Nucl Radiat &

Nucl Energy Technol Shanghai 201800 Peoples R China;

Xian Res Inst Hitech Xian Shaanxi Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

Chinese Acad Sci Shanghai Inst Appl Phys Key Lab Nucl Radiat &

Nucl Energy Technol Shanghai 201800 Peoples R China;

Soochow Univ Sch Radiol &

Interdisciplinary Sci RAD X Suzhou 215123 Jiangsu Peoples R China;

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Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level

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