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首页> 外文期刊>Diabetes care >Age at menopause, reproductive life span, and type 2 diabetes risk: Results from the EPIC-InterAct study
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Age at menopause, reproductive life span, and type 2 diabetes risk: Results from the EPIC-InterAct study

机译：更年期，生殖寿命和2型糖尿病风险的年龄：史史 - 互动研究的结果

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摘要

OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86- 1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and ??55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age atmenopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. ? 2013 by the American Diabetes Association.
机译：期更年期的客观年龄是未来健康结果的重要决定因素，但对其与2型糖尿病的关系很少。我们审查了绝经年龄和生殖生活跨度（绝经年龄减去营养年龄）的联想，糖尿病风险。研究设计和方法 - 从互动研究中获得了数据，一项预期案例 - 队列研究嵌套在欧洲癌症和营养的前瞻性调查中。共有3,691型糖尿病案例和4,408个副枢轴成员均包含在分析中，中位随访11年。普雷斯加权Cox比例危害模型调整了年龄，已知的糖尿病风险因素，以及BMI，腰围和吸烟的生殖因素和生殖因素的效果改性。屈曲 - 平均（SD）年龄为59.2（5.8）年。在多变量调节后，2型糖尿病的危险比（HRS）为1.32（95％CI 1.04-1.69），1.09（0.90-1.31），0.97（0.86-1.10）和更年期妇女的妇女的0.85（0.70-1.03）相对于50-54岁年龄的人，分别为<40,40-44,45-49和55岁。每个SD的人力计年龄较小的atmenopause为1.08（1.02-1.14）。同样，较短的生殖寿命与较高的糖尿病风险有关（每个SD较低的生殖寿命跨度1.06 [1.01-1.12]）。观察到BMI，腰围或吸烟没有影响（P相互作用）。结论 - 早期更年期与2型糖尿病的风险有关。还是2013年由美国糖尿病协会。

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  • 来源
    《Diabetes care》 |2013年第4期|共8页
  • 作者

    BrandJ.S.; VanDerSchouwY.T.; Onland-MoretN.C.; SharpS.J.; OngK.K.; KhawK.-T.; ArdanazE.; AmianoP.; BoeingH.; ChirlaqueM.-D.; Clavel-ChapelonF.; CroweF.L.; DeLauzon-GuillainB.; DuellE.J.; FagherazziG.; FranksP.W.; GrioniS.; GroopL.C.; KaaksR.; KeyT.J.; NilssonP.M.; OvervadK.; PalliD.; PanicoS.; QuirósJ.R.; RolandssonO.; SacerdoteC.; SánchezM.-J.; SlimaniN.; TeucherB.; TjonnelandA.; TuminoR.; VanDerAD.L.; FeskensE.J.M.; LangenbergC.; ForouhiN.G.; RiboliE.; WarehamN.J.;

  • 作者单位

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht;

    Medical Research Council Epidemiology Unit Institute of Metabolic Science Addenbrooke's Hospital;

    Medical Research Council Epidemiology Unit Institute of Metabolic Science Addenbrooke's Hospital;

    Department of Public Health and Primary Care University of Cambridge Addenbrooke's Hospital;

    Navarre Public Health Institute Pamplona Spain Consortium for Biomedical Research in;

    Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain Public Health;

    Department of Epidemiology German Institute of Human Nutrition Potsdam-Rehbruecke Nuthetal;

    Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain Department of;

    INSERM Centre for Research in Epidemiology and Population Health (CESP) U1018: Nutrition;

    Cancer Epidemiology Unit Nuffield Department of Clinical Medicine University of Oxford Oxford;

    INSERM Centre for Research in Epidemiology and Population Health (CESP) U1018: Nutrition;

    Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program L'Hospitalet de;

    INSERM Centre for Research in Epidemiology and Population Health (CESP) U1018: Nutrition;

    Department of Clinical Sciences Malm? General Hospital Lund University Malm? Sweden Department;

    Fondazione IRCCS Istituto Nazionale Tumori di Milano Milan Italy;

    Department of Clinical Sciences Diabetes and Endocrinology University Hospital Scania Lund;

    Division of Cancer Epidemiology German Cancer Research Centre Heidelberg Germany;

    Cancer Epidemiology Unit Nuffield Department of Clinical Medicine University of Oxford Oxford;

    Department of Clinical Sciences University Hospital Scania Lund University Malm? Sweden;

    Department of Epidemiology School of Public Health Aarhus University Aarhus Denmark Department;

    Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute Florence;

    Department of Clinical and Experimental Medicine Federico II University Naples Italy;

    Consejería de Sanidad Public Health Oviedo-Asturias Spain;

    Department of Public Health and Clinical Medicine Family Medicine Umea University Umea Sweden;

    Center for Cancer Prevention (CPO-Piemonte) Torino Italy Human Genetic Foundation Torino Italy;

    Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain Andalusian;

    International Agency for Research on Cancer Dietary Exposure Assessment Group Lyon France;

    Division of Cancer Epidemiology German Cancer Research Centre Heidelberg Germany;

    Danish Cancer Society Research Center Strandboulevarden Copenhagen Denmark;

    Cancer Registry and Histopathology Unit Civile - M.P. Arezzo Hospital Azienda Sanitaria;

    National Institute for Public Health and the Environment Bilthoven Netherlands;

    Section of Nutrition and Epidemiology Division of Human Nutrition University of Wageningen;

    Medical Research Council Epidemiology Unit Institute of Metabolic Science Addenbrooke's Hospital;

    Medical Research Council Epidemiology Unit Institute of Metabolic Science Addenbrooke's Hospital;

    Department of Epidemiology and Biostatistics School of Public Health Imperial College London;

    Medical Research Council Epidemiology Unit Institute of Metabolic Science Addenbrooke's Hospital;

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  • 中图分类 内分泌腺疾病及代谢病;
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