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首页> 外文期刊>Diabetes care >Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study
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Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study

机译：早期生活饥荒，理想的心血管健康指标，以及事件糖尿病的风险：4C研究的结果

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OBJECTIVE We aim to investigate the impact of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and adulthood diabetes risk. RESEARCH DESIGN AND METHODS This study included 77,925 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study who were born around the time of the Chinese Great Famine and free of diabetes at baseline. They were divided into three famine exposure groups according to the birth year, including nonexposed (1963-1974), fetal exposed (1959-1962), and childhood exposed (1949-1958). Relative risk regression was used to examine the associations between famine exposure and ICVHMs on diabetes. RESULTS During a mean follow-up of 3.6 years, the cumulative incidence of diabetes was 4.2%, 6.0%, and 7.5% in nonexposed, fetal-exposed, and childhood-exposed participants, respectively. Compared with nonexposed participants, fetal-exposed but not childhood-exposed participants had increased risks of diabetes, with multivariable-adjusted risk ratios (RRs) (95% CIs) of 1.17 (1.05-1.31) and 1.12 (0.96-1.30), respectively. Increased diabetes risks were observed in fetal-exposed individuals with nonideal dietary habits, nonideal physical activity, BMI >= 24.0 kg/m(2), or blood pressure >= 120/80 mmHg, whereas significant interaction was detected only in BMI strata (Pfor interaction = 0.0018). Significant interactions have been detected between number of ICVHMs and famine exposure on the risk of diabetes (Pfor interaction = 0.0005). The increased risk was observed in fetal-exposed participants with one or fewer ICVHMs (RR 1.59 [95% CI 1.24-2.04]), but not in those with two or more ICVHMs. CONCLUSIONS The increased risk of diabetes associated with famine exposure appears to be modified by the presence of ICVHMs.
机译：目标我们的目标是探讨理想心血管健康指标（ICVHMS）对饥荒暴露和成年性糖尿病风险的关联的影响。研究设计和方法本研究包括来自中国心肌斑和癌症群体（4C）研究的77,925名参与者，谁在中国伟大的饥荒时出生，并在基线上没有糖尿病。根据诞生年份，它们分为三个饥荒，包括（1963-1974），胎儿暴露（1959-1962）和童年（1949-1958）。相对风险回归用于检查糖尿病患者饥荒暴露和ICVHM之间的关联。在平均随访3.6岁期间，糖尿病累积发病率分别为4.2％，6.0％和7.5％，分别为胎儿暴露，儿童暴露的参与者。与非缺乏的参与者相比，胎儿暴露但不是儿童暴露的参与者增加了糖尿病的风险，多变量调整的风险比（RRS）（95％CIS）分别为1.17（1.05-1.31）和1.12（0.96-1.30） 。在胎儿暴露的个体中观察到胎儿饮食习性的糖尿病患者增加，非外膜体育，BMI> = 24.0kg / m（2），或血压> = 120/80mmHg，而仅在BMI Strata中检测到显着的相互作用（ P fol Interaction = 0.0018）。在糖尿病风险的ICVHMS和饥荒暴露之间检测到显着的相互作用（PFOR相互作用= 0.0005）。在胎儿暴露的参与者中观察到具有一个或更少的ICVHMS（RR 1.59 [95％CI 1.24-2.04]）的增加的风险，但不在具有两个或更多个ICVHM的人中。结论通过ICVHMS存在，似乎增加了与饥荒接触相关的糖尿病风险增加。

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