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首页> 外文期刊>International Journal of Cardiology >Childhood lifestyle and clinical determinants of adult ideal cardiovascular health: The Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Princeton Follow-up Study
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Childhood lifestyle and clinical determinants of adult ideal cardiovascular health: The Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Princeton Follow-up Study

机译：成人理想心血管健康的儿童生活方式和临床决定因素：年轻芬兰人的心血管风险研究，成人健康的儿童决定因素研究，普林斯顿后续研究

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Background The American Heart Association recently defined ideal cardiovascular health by simultaneous presence of seven health behaviors and factors. The concept is associated with cardiovascular disease incidence, and cardiovascular disease and all-cause mortality. To effectively promote ideal cardiovascular health already early in life, childhood factors predicting future ideal cardiovascular health should be investigated. Our aim was thus to comprehensively explore childhood determinants of adult ideal cardiovascular health in population based cohorts from three continents. Methods The sample comprised a total of 4409 participants aged 3-19 years at baseline from the Cardiovascular Risk in Young Finns Study (YFS; N = 1883) from Finland, Childhood Determinants of Adult Health Study (CDAH; N = 1803) from Australia and Princeton Follow-up Study (PFS; N = 723) from the United States. Participants were re-examined 19-31 years later when aged 30-48 years. Results In multivariable analyses, independent childhood predictors of adult ideal cardiovascular health were family socioeconomic status (P < 0.01; direct association) and BMI (P < 0.001; inverse association) in all cohorts. In addition, blood pressure (P = 0.007), LDL-cholesterol (P < 0.001) and parental smoking (P = 0.006) in the YFS, and own smoking (P = 0.001) in CDAH were inversely associated with future ideal cardiovascular health. Conclusions Among several lifestyle and clinical indicators studied, higher family socioeconomic status and non-smoking (parental/own) in childhood independently predict ideal cardiovascular health in adulthood. As atherosclerotic cardiovascular diseases are rooted in childhood, our findings suggest that special attention could be paid to children who are from low socioeconomic status families, and who smoke or whose parents smoke, to prevent cardiovascular disease morbidity and mortality.
机译：背景技术美国心脏协会最近通过同时存在七个健康行为和因素来定义理想的心血管健康。该概念与心血管疾病的发病率，心血管疾病和全因死亡率有关。为了有效地促进早已达到理想的心血管健康，应该研究预测未来理想的心血管健康的儿童因素。因此，我们的目标是在三大洲基于人群的队列中全面探讨成人理想心血管健康的儿童决定因素。方法该样本包括来自芬兰的年轻芬兰人心血管风险研究（YFS; N = 1883），来自澳大利亚的儿童期成人健康决定因素（CDAH; N = 1803），基线时年龄为3-19岁的4409名参与者。美国的普林斯顿后续研究（PFS; N = 723）。年龄在30-48岁之间的参与者在19-31年后接受了重新检查。结果在多变量分析中，在所有队列中，成人理想心血管健康的独立儿童预测因子为家庭社会经济状况（P <0.01;直接关联）和BMI（P <0.001;反向关联）。此外，YFS中的血压（P = 0.007），LDL-胆固醇（P <0.001）和父母吸烟（P = 0.006）以及CDAH中的自身吸烟（P = 0.001）与将来理想的心血管健康呈负相关。结论在所研究的几种生活方式和临床指标中，较高的家庭社会经济地位和儿童时期的禁烟（父母/自己的父母）独立地预测了成年后的理想心血管健康。由于动脉粥样硬化性心血管疾病源于儿童期，因此我们的研究结果表明，应特别注意来自社会经济地位低下的家庭，吸烟或父母吸烟的儿童，以预防心血管疾病的发病率和死亡率。

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