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首页> 外文期刊>Diabetes care >Association Between Glycemic Status and the Risk of Parkinson Disease: A Nationwide Population-Based Study
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Association Between Glycemic Status and the Risk of Parkinson Disease: A Nationwide Population-Based Study

机译：血糖地位与帕金森病的风险：全国范围的人口研究

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摘要

OBJECTIVE Previous studies have suggested that diabetes increases the risk of Parkinson disease (PD); however, this has not been conclusively established. We analyzed the risk of PD based on baseline glucose tolerance status in a large-scale cohort representative of the general Korean population. RESEARCH DESIGN AND METHODS This analysis was performed in a cohort of 15,168,021 adults aged >= 40 years who underwent health checkups under the National Health Insurance Service between January 2009 and December 2010. The clinical course of subjects was monitored until December 2016. Subjects were classified into the following groups: no diabetes, impaired fasting glucose (IFG), diabetes duration = 5 years. We analyzed the adjusted hazard ratio of PD for each group. RESULTS During the observation period of 49,076,148.74 person-years, PD occurred in 31,577 patients. Compared with the nondiabetes group, the adjusted hazard ratio was 1.038 (95% CI, 1.009-1.067) in the IFG group, 1.185 (95% CI, 1.143-1.229) in the diabetes duration = 5 years group. These results were consistent with those of the subgroup analysis, and the presence of diabetes further increased the risk of PD regardless of comorbidities such as cardiovascular, cerebrovascular, and chronic kidney diseases. CONCLUSIONS This population-based cohort study suggests that diabetes is an independent risk factor for PD.
机译：目的以前的研究表明，糖尿病增加了帕金森病的风险（PD）;但是，这尚未结识。我们根据韩国人群的大规模队列代表的大规模群体基于基线葡萄糖耐量状态分析了PD的风险。研究设计和方法该分析是在15,168,021名成年人的队列中进行的，= 40岁的成人= 40岁，在2009年1月至2010年1月期间的国家健康保险服务下进行了健康检查。受试者的临床进程被监测到2016年12月。受试者被分类进入以下群体：无糖尿病，空腹葡萄糖（IFG）受损，糖尿病持续时间= 5年。我们分析了每组PD的调整后危险比。结果在观察期为49,076,148.74人 - 年，PD发生在31,577名患者中。与NondiaBetes组相比，IFG组的调整后危险比为1.038（95％CI，1.009-1.067），1.185（95％CI，1.143-1.229），糖尿病持续时间= 5年组。这些结果与亚组分析的结果一致，糖尿病的存在进一步增加了PD的风险，而不管心血管，脑血管和慢性肾病等合并症。结论该群体的队列研究表明，糖尿病是PD的独立危险因素。

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  • 来源
    《Diabetes care》 |2020年第9期|共7页
  • 作者

    Rhee Sang Youl; Han Kyung-Do; Kwon Hyemi; Park Se-Eun; Park Yong-Gyu; Kim Yang-Hyun; Yoo Soon-Jip; Rhee Eun-Jung; Lee Won-Young;

  • 作者单位

    Kyung Hee Univ Dept Endocrinol &

    Metab Sch Med Seoul South Korea;

    Catholic Univ Coll Med Dept Med Stat Seoul South Korea;

    Sungkyunkwan Univ Sch Med Div Endocrinol &

    Metab Dept Internal Med Kangbuk Samsung Hosp Seoul;

    Sungkyunkwan Univ Sch Med Div Endocrinol &

    Metab Dept Internal Med Kangbuk Samsung Hosp Seoul;

    Catholic Univ Coll Med Dept Med Stat Seoul South Korea;

    Korea Univ Coll Med Dept Family Med Seoul South Korea;

    Catholic Univ Korea Div Endocrinol &

    Metab Dept Internal Med Bucheon St Marys Hosp Coll Med;

    Sungkyunkwan Univ Sch Med Div Endocrinol &

    Metab Dept Internal Med Kangbuk Samsung Hosp Seoul;

    Sungkyunkwan Univ Sch Med Div Endocrinol &

    Metab Dept Internal Med Kangbuk Samsung Hosp Seoul;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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