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首页> 外文期刊>Current opinion in pharmacology >Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine.
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Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine.

机译：超越奖励假说：伏伏核多巴胺的替代功能。

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According to the dopamine (DA) hypothesis of reward, DA systems in the brain, particularly in the nucleus accumbens, are thought to directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food, water and sex, as well as various drugs of abuse. However, there are numerous problems associated with this hypothesis. Interference with accumbens DA transmission does not substantially blunt primary motivation for natural rewards such as food, but it does disrupt the propensity of animals to engage in effortful responding to obtain food. Electrophysiological and voltammetric studies indicate that novel stimuli, conditioned stimuli that predict reward, and instrumental behaviors that deliver natural rewards all act to stimulate DA activity. Accumbens DA acts as a modulator of several functions related to motivated behavior, and can influence normal and pathological cognitive function, activational aspects of motivation, anergia or psychomotor slowing in depression, the impact of conditioned stimuli, plasticity and a variety of sensorimotor functions.
机译：根据奖励的多巴胺（DA）假说，人们认为大脑（尤其是伏隔核）中的DA系统直接介导食物，水和性等自然刺激物以及各种药物的奖励或主要动机特征虐待。但是，与此假设相关的问题很多。干扰伏打动物的DA传播并不能在本质上减弱诸如食物之类的自然奖励的主要动机，但是它确实破坏了动物为了获得食物而做出努力响应的倾向。电生理和伏安法研究表明，新的刺激，预测奖励的条件刺激以及提供自然奖励的工具行为都可以刺激DA活动。 Accumbens DA充当与动机行为相关的多种功能的调节剂，并且可以影响正常和病理认知功能，动机的激活方面，抑郁症的无痛或精神运动减慢，条件刺激的影响，可塑性和多种感觉运动功能。

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