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首页> 外文期刊>Current opinion in pharmacology >Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving.
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Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving.

机译:治疗药物成瘾和渴望的新型药物治疗方法。

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摘要

Pharmacological agents have shown limited efficacy and consistency in the treatment of drug addiction. Hence, the development of new medications with improved long-term efficacy and reduced side effects should be given a high priority given the costs to society associated with drug abuse and drug-related pathologies. Neurochemical systems can be significantly altered by repeated exposure to drugs of abuse. These long-term molecular and neurochemical changes might, in turn, explain the core features of addiction--the compulsive seeking and taking of the drug--as well as the risk of relapse.
机译:药理学药剂在治疗药物成瘾方面显示出有限的功效和一致性。因此,考虑到与药物滥用和与药物相关的病理相关的社会成本,应优先开发具有改善的长期疗效和减少的副作用的新药物。反复接触滥用药物会严重改变神经化学系统。这些长期的分子和神经化学变化可能反过来解释了成瘾的核心特征-强迫性寻求和服用该药物-以及复发的风险。

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