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首页> 外文期刊>Journal of Animal Science >Evaluation of responses to vaccination of Angus cattle for four viruses that contribute to bovine respiratory disease complex
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Evaluation of responses to vaccination of Angus cattle for four viruses that contribute to bovine respiratory disease complex

机译：评估对牛呼吸道疾病复合物有贡献的四种病毒的Angus牛接种的反应

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Although vaccination is an effective measure in reducing the risk of bovine respiratory disease complex (BRDC) in cattle, BRDC losses remain significant. Increasing the efficacy of vaccination depends on elucidating the protective immune response to different antigens included in vaccines, determining the best timing for vaccination, and understanding the impact of the age of the calf on vaccination. This study measured the serum antibodies present in calves following vaccination against 4 viruses commonly associated with BRDC: bovine viral diarrhea virus type 1 and 2 (BVDV1 and BVDV2), bovine respiratory syncytial virus (BRSV), and bovine herpesvirus 1 (BHV1). Serum antibody titers were measured in more than 1,600 calves at 3-wk intervals starting at the time of the first vaccination. This first vaccination occurred at weaning for approximately half of the individuals and 3 wk before weaning for the other half. Dam age (years), time of weaning (initial vaccination or booster vaccination), and age of calf within year-season (days within year-season) classification all were found to have a significant effect on measured traits such as the initial titer and overall response. An increased initial titer was negatively correlated with each response trait (initial, booster, and overall response). Calves that were weaned at initial vaccination had greater overall antibody response to BVDV1 and BVDV2 compared with calves weaned 3 wk before initial vaccination. In contrast, calves given their initial vaccination 3 wk before weaning had greater overall antibody response to BRSV and BHV1 compared with calves that were vaccinated at weaning. Furthermore, the circulating antibody titer at which each virus needed to be below for an individual calf to positively respond to vaccination was determined (log(2) titer of 0.38 for BVDV1, 1.5 for BVDV2, 3.88 for BRSV, and 1.5 for BHV1). This information can be used to improve vaccination protocols to allow for a greater response rate of individuals to vaccination and, hopefully, improved protection.
机译：虽然疫苗接种是在减少牛牛呼吸系统疾病复合物（BRDC）的风险的有效措施，BRDC损耗保持显著。增加疫苗接种的功效取决于阐明的保护性免疫响应于包括在疫苗不同的抗原，确定用于疫苗接种的最佳时机，并了解第接种小腿的年龄的影响。本研究中测量的本血清抗体在小腿以下针对4种通常与BRDC相关病毒的疫苗接种：牛病毒性腹泻病毒1型和2（BVDV1和BVDV2），牛呼吸道合胞病毒（BRSV），牛疱疹病毒1（BHV1）。在开始在第一次疫苗接种的时间3周的间隔在超过1600头牛犊测定血清抗体滴度。这第一次接种发生在断奶另一半断奶前大约一半的个人和3周。大坝年龄（岁），断奶（初次接种或加强免疫接种中），与去年赛季中小牛的年龄（岁的季天之内）的分类所有的时间被发现有上测量性状的显著效果如初始滴度和总体响应。增加的初始滴度负的响应特性（初始的，助力器，和总体反应）相关。与小牛相比断奶3周初次接种之前在初始接种断奶该小牛具有更大的总抗体应答BVDV1和BVDV2。与此相反，牛犊给出它们的初始疫苗接种3周前用在断奶接种该小牛断奶相比具有更大的总抗体应答BRSV和BHV1。此外，在其中每个病毒需要的是下面针对单个小牛接种疫苗积极响应的循环抗体效价测定（对于BVDV1，1.5 BVDV2，3.88为BRSV，和1.5 BHV1 0.38日志（2）效价）。这些信息可以用来提高疫苗接种方案，允许个人接种更大的响应速度，并希望能更好的保护。

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