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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Microbial Cell Factories for the Production of Terpenoid Flavor and Fragrance Compounds
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Microbial Cell Factories for the Production of Terpenoid Flavor and Fragrance Compounds

机译：用于生产Terpenoid风味和香味化合物的微生物细胞工厂

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摘要

Terpenoid flavor and fragrance compounds are of high interest to the aroma industry. Microbial production offers an alternative sustainable access to the desired terpenoids independent of natural sources. Genetically engineered microorganisms can be used to synthesize terpenoids from cheap and renewable resources. Due to its modular architecture, terpenoid biosynthesis is especially well suited for the microbial cell factory concept: a platform host engineered for a high flux toward the central C-5 prenyl diphosphate precursors enables the production of a broad range of target terpenoids just by varying the pathway modules converting the C-5 intermediates to the product of interest. In this review typical terpenoid flavor and fragrance compounds marketed or under development by biotech and aroma companies are given, and the specificities of the aroma market are discussed. The main part of this work focuses on key strategies and recent advances to engineer microbes to become efficient terpenoid producers.
机译：Terpenoid风味和香味化合物对香气行业具有很高的兴趣。微生物生产提供替代可持续的可持续接入所需的三萜类化合物，与天然来源无关。基因工程化微生物可用于合成来自廉价和可再生资源的三萜类化。由于其模块化架构，Terpenoid生物合成尤其适用于微生物细胞厂概念：用于高通量朝向中央C-5戊烯二磷酸前体的平台主持人能够通过改变来生产广泛的靶萜类化合物。路径模块将C-5中间体转换为感兴趣的产品。在本综述中，给出了Biotech和Aroma公司销售或正在开发的典型的萜类香味和香味化合物，并讨论了香气市场的特殊性。这项工作的主要部分侧重于将工程师微生物的关键策略和最近进步成为高效的萜类生产者。

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